Bimodal Mesoporous Silicas Functionalized with Different Level and Species of the Amino Groups for Adsorption and Controlled Release of Aspirin
Bimodal Mesoporous Silicas Functionalized with Different Level and Species of the Amino Groups for Adsorption and Controlled Release of Aspirin
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不同水平和种类氨基功能化的双峰介孔二氧化硅用于阿司匹林的吸附和控释
DOI：
10.1166/jnn.2011.4237
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发表时间：
2011-08-01
影响因子：
--
通讯作者：
Zhang, Li
中科院分区：
文献类型：
--
作者：
Gao, Lin;Sun, Jihong;Zhang, Li
采用后接枝的方法合成了小孔尺寸在2.9 nm左右、大孔尺寸在20 nm左右的改性双峰介孔材料。为了研究功能化BMMS在药物释放中的应用，以阿司匹林为模型药物，进行了载药和释药曲线的研究。用X射线衍射仪、扫描电子显微镜、透射电子显微镜、氮气吸附、FT-IR、Si-29-核磁共振、热重和紫外可见光谱对相关样品进行了表征。通过介孔表面羟基与3-氨丙基三乙氧基硅烷(N-TES)或3-(2-氨乙氨基)丙基三甲氧基硅烷(NN-TES)之间的弱化学作用或氢键作用进行接枝改性。结果表明，不同数量的N-TES基团和NN-TES基团成功地包覆在介孔表面。随后，我们详细研究了修饰后的BMMS的阿司匹林控释性能。阿司匹林吸附实验表明，改性BMMS对阿司匹林的吸附容量随N-TES基团含量的增加而提高，且在相同的改性比例下，NN-TES功能化样品的吸附容量高于N-TES改性样品。最主要的原因是NN-TES基团与阿司匹林分子之间的相互作用强于N-TES基团与阿司匹林分子之间的相互作用。体外实验表明，阿司匹林的释放行为主要取决于介孔载体中官能团的数量和种类的变化。根据Korsmeyer-Peppas模型，发现动力学释放常数k随改性BMMS中孔表面氨基含量的增加而减小，表明表面有机基团直接影响BMMS孔内阿司匹林的释放速率。所有情况下的释药指数n均大于0.5，表明药物释放机理符合扩散型的非Fickian模型。因此，这类材料在药物控制释放方面具有很强的应用潜力。
The synthesis of modified bimodal mesoporous materials (BMMs) with a small pore size of around 2.9 nm and a large pore size of about 20 nm has been performed via post-grafting methods. To study the application of functionalized BMMs in drug delivery, loading and releasing profiles using aspirin as model drug were carried out. XRD, SEM, TEM, N-2 adsorption, FT-IR, Si-29-NMR, TG and UV-Vis spectroscopy were used to characterize the related samples. The post-grafting modification was performed through the weak chemical interaction or hydrogen bonding in between OH groups of the mesopore surface and 3-aminopropyltriethoxysilane (N-TES) or 3-(2-aminoethylamino) propyltrimethoxysilane (NN-TES). The results showed that N-TES groups with different amount and NN-TES groups were successfully incorporated onto the mesopore surface. Subsequently, the controlled aspirin delivery properties from the resulting modified BMMs were investigated in detail. The aspirin adsorption experiments indicated that the adsorption capacities of modified BMMs were improved with the increasing amount of N-TES groups, while the NN-TES functionalized samples showed higher adsorption capacity than N-TES modified samples with the same ratio of modification. The most reason is that the interaction between the NN-TES groups and aspirin molecules is stronger than that between the N-TES groups and aspirin molecules. The in vitro tests exhibited that aspirin release behaviors mainly depended on the variation of the amount and species of the functional groups in mesoporous carries. According to the Korsmeyer-Peppas model, it is found that the kinetic release constant k reduced with the increase amount of the amino groups on the mesopore surface of modified BMMs, suggesting that the aspirin release rate from the pores of BMMs was influenced directly by organic groups on the surface. The release exponent n of all the situations were above 0.5, indicating the drug release mechanism followed a non-Fickian model that was diffusion based. Therefore, this type of materials described in this paper is of strong potential for the controlled drug release applications.