Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes
Chorioamnionitis increases neonatal morbidity in pregnancies complicated by preterm premature rupture of membranes
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DOI：
10.1016/j.ajog.2004.11.035
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发表时间：
2005-04-01
影响因子：
9.8
通讯作者：
Carlo, W
中科院分区：
文献类型：
--
作者：
Ramsey, PS;Lieman, JM;Carlo, W
目的：比较早产胎膜早破后发生绒毛膜炎的妇女与未发生绒毛膜炎的妇女所生新生儿的发病率。研究设计：我们回顾了24周或更长时间内确诊为早产胎膜早破的单胎妊娠的结局，这些妊娠导致分娩少于37周。早产胎膜早破的治疗包括使用抗生素，如果小于32周，最好使用抗生素，以及在34周或更长时间进行期待治疗和诱导。复合新生儿重大和轻微的发病率进行了比较妊娠并发绒毛膜炎和那些now.Results：从1998年8月至2000年8月，430例早产，胎膜破裂6003分娩（7.2%）确定。13%的胎膜早破妇女（56/430）发生绒毛膜炎。随着胎龄的降低，绒毛膜羊水炎的发病率显着增加。母亲患绒毛膜炎的新生儿综合主要发病率（55%）显著高于母亲未患绒毛膜炎的新生儿（18%，P
Objective: To compare morbidities of neonates born to women who developed chorioamnionitis after premature preterm rupture of membranes versus those who did not.Study design: We reviewed outcomes in singleton pregnancies with confirmed premature preterm rupture of membranes at 24 weeks or beyond that resulted in delivery less than 37 weeks. Management of premature preterm rupture of membranes included the use of antibiotics, betamethasone if less than 32 weeks, and expectant management with induction at 34 weeks or greater. Composite neonatal major and minor morbidity rates were compared between pregnancies complicated by chorioamnionitis and those that were not.Results: From August 1998 to August 2000, 430 cases of premature preterm, rupture of membranes were identified among 6003 deliveries (7.2%). Thirteen percent of women (56/430) with premature preterm rupture of membranes developed chorioamnionitis. The incidence of chorioamnionitis increased significantly with decreasing gestational age. The composite neonatal major morbidity rate was significantly higher in neonates whose mothers developed chorioamnionitis (55%) versus those who did not (18%, P