Changes in health outcomes as a function of abstinence and reduction in illicit psychoactive drug use: a prospective study in primary care.
Changes in health outcomes as a function of abstinence and reduction in illicit psychoactive drug use: a prospective study in primary care.
复制标题
健康结果的变化作为戒断和减少非法精神活性药物使用的函数：初级保健的一项前瞻性研究。
DOI：
10.1111/add.13020
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Saitz,Richard
中科院分区：
文献类型：
--
作者：
Park,TaeWoo;Cheng,DebbieM;Lloyd-Travaglini,ChristineA;Bernstein,Judith;Palfai,TiborP;Saitz,Richard
AimsTo test (1) whether abstinence and reduction in illicit psychoactive drug use were associated with changes in health outcomes in primary care patients and (2) whether these associations varied by drug type.DesignSecondary analysis of data from a randomized controlled trial that tested a brief intervention for drug use in primary care patients (589 enrolled, 574 completed a 6‐month assessment). Analyses were conducted overall and stratified by the most commonly self‐identified main drugs (marijuana, cocaine and opioids).Setting and ParticipantsPatients who screened positive for illicit drug use at an urban primary care clinic in Boston, Massachusetts, USA.MeasurementsDifferences in past‐month main drug use at baseline and 6‐month outcome were categorized as continued or increased use, decreased use without abstinence and abstinence. Primary outcomes were 6‐month changes in drug use consequences [Short Inventory of Problems scores (range 0–45)], depressive symptoms and health‐related quality of life (HRQol).FindingsAbstinence was associated with a greater decrease in adverse drug use consequences than continued or increased use among the full sample and cocaine and opioids subgroups (adjusted means, full sample: –8.11 versus –0.05,P< 0.001; cocaine: –13.33 versus +1.09,P< 0.001, opioids; –16.84 versus –2.10,P< 0.001). Differences were not significant between those who decreased use compared with those who continued or increased use. There were no significant associations between drug use and depressive symptoms or HRQol. Neither abstinence nor decreased use was associated significantly with consequences in the marijuana subgroup.ConclusionsAmong primary care patients in the United States who use illicit psychoactive drugs, abstinence but not reduction in use without abstinence appears to be associated with decreased adverse drug use consequences.
