WOUND-HEALING IN THE BOTTLENOSE DOLPHIN (TURSIOPS-TRUNCATUS)
WOUND-HEALING IN THE BOTTLENOSE DOLPHIN (TURSIOPS-TRUNCATUS)
复制标题
DOI：
10.1139/f85-029
复制
发表时间：
1985-01-01
影响因子：
2.4
通讯作者：
GERACI, JR
中科院分区：
文献类型：
--
作者：
BRUCEALLEN, LJ;GERACI, JR
3只宽吻海豚（T. truncatus）的早期愈合阶段具有特征。在真皮上切开6个10厘米长、2毫米深的切口，注入无菌海水30分钟。在第2、6和12小时以及第1、2、3、7和10天对切口的所有表面进行活检。组织学上，6-72小时的伤口以中性粒细胞为主的混合细胞浸润和大面积的表皮内囊泡为特征。迁移的表皮细胞在第2天完成了切口间隙的桥接，而基底细胞有丝分裂活性的升高在第7天恢复了完全的表皮厚度。值得注意的是没有传统的结痂；它的作用是由表皮细胞和囊泡的转化屏障层起作用。同时，细胞内异常分布的黑色素素体也代表了新的表皮细胞。Tursiops愈合的顺序和时间与陆生哺乳动物相似；愈合外观的差异很可能是由于对水生生活方式的适应。
Early stages of would healing were characterized in 3 bottlenose dolphins (T. truncatus). A total of six 10-cm long, 2-mm-deep incisions into the dermis were infused with sterile seawater for 30 min. Biopsies representing all surfaces of the cuts were taken at 2, 6 and 12 h and 1, 2, 3, 7 and 10 days. Histologically, wounds from 6-72 h were characterized by a mixed cell infiltrate predominated by neutrophils and extensive areas of intraepidermal vesicles. Migrating epidermal cells bridged the incisional gap by 2 days while elevated mitotic activity of basal cells restored full epidermal thickness by day 7. Notable was the absence of a traditional scab; its purpose was served by a transformed barrier layer of epidermal cells and vesicles. As well, an abnormal intracellular distribution of melanosomes typified new epidermal cells. The sequence and timing of healing in Tursiops are similar to those reported in terrestrial mammals; differences in the appearance of healing are most likely due to adaptations to an aquatic lifestyle.