Clinical practice. Primary ovarian insufficiency.
Clinical practice. Primary ovarian insufficiency.
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DOI：
10.1056/nejmcp0808697
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发表时间：
2009-02-05
期刊：
影响因子：
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通讯作者：
Nelson LM
中科院分区：
文献类型：
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作者：
Nelson LM
一位30岁女性，自6个月前停止服用口服避孕药以怀孕以来，一直没有月经。她经历了青春期，在时间和发育方面都是正常的，初潮是在12岁。18岁时，她开始服用口服避孕药治疗月经不调。她说工作压力很大。她的体重为59公斤，身高为1.66米;她的身体质量指数（体重（公斤）除以身高（米）的平方）为21.3。没有乳汁分泌，多毛症，或痤疮。盆腔检查正常，妊娠试验阴性，催乳素水平正常，卵泡刺激素（FSH）水平在绝经期范围内。应该如何评估和治疗？
A 30-year-old woman presents with a history of no menses since she stopped taking oral contraceptives 6 months ago in order to conceive. She had undergone puberty that was normal in both timing and development, with menarche at 12 years of age. At 18 years of age, she started taking oral contraceptives for irregular menses. She reports stress at work. Her weight is 59 kg, and her height 1.66 m; her body-mass index (the weight in kilograms divided by the square of the height in meters) is 21.3. There is no galactorrhea, hirsutism, or acne. The pelvic examination is normal, a pregnancy test is negative, the prolactin level is normal, and the follicle-stimulating hormone (FSH) level is in the menopausal range. How should she be evaluated and treated?