Studies on the biological effects of ozone: 6. Production of transforming growth factor 1 by human blood after ozone treatment.
Studies on the biological effects of ozone: 6. Production of transforming growth factor 1 by human blood after ozone treatment.
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臭氧生物效应研究： 6. 人体血液经臭氧处理后产生转化生长因子1。
DOI：
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发表时间：
1994
影响因子：
3.2
通讯作者：
S. Silvestri
中科院分区：
文献类型：
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作者：
V. Bocci;E. Luzzi;F. Corradeschi;S. Silvestri
在将正常志愿者的人全血暴露于浓度范围为22至156微克/毫升的臭氧后，我们已经表明，在孵育长达8小时后，转化生长因子β（TGF-β 1）显著释放。与TGF-β 1相比，TGF-β 2的产生不受臭氧浓度的影响。与我们先前的发现一致，似乎在肝素和5 mM Ca，2+存在下，血液允许持续产生肿瘤坏死因子a（TNF α）并释放低且无害水平的游离血红蛋白。这些数据支持这样的论点，即用臭氧处理血液后再输注到供体中进行自血疗法，可能代表了一种有价值的治疗方法，用于实现免疫调节作用。
After exposing human whole blood from normal volunteers to ozone concentrations ranging from 22 to 156 micrograms/ml, we have shown that, upon incubation of up to 8 hours, there is a significant release of transforming growth factor beta (TGF-beta 1). In comparison to TGF-beta 1, TGF-beta 2 production is not influenced by ozone concentrations. In line with our previous findings it appears that blood, in the presence of heparin and 5mM Ca,2+ allows a consistent production of tumor necrosis factor a (TNF alpha) and the release of low and non-hazardous levels of free hemoglobin. These data support the contention that autohemotherapy performed after treating blood with ozone followed by reinfusion into the donor, may represent a valuable therapeutic approach for achieving immunoregulatory effects.