Improving Antibiotic Activity against Wound Pathogens with Manuka Honey In Vitro
Improving Antibiotic Activity against Wound Pathogens with Manuka Honey In Vitro
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DOI：
10.1371/journal.pone.0045600
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发表时间：
2012-09-26
期刊：
影响因子：
3.7
通讯作者：
Cooper, Rose
中科院分区：
文献类型：
--
作者：
Jenkins, Rowena;Cooper, Rose
在发现氧苄西林和麦卢卡蜂蜜对耐甲氧西林金黄色葡萄球菌的协同作用后，本研究旨在寻找抗生素和蜂蜜的进一步协同组合，可能在治疗伤口方面具有潜力。采用圆盘扩散法、肉汤稀释法、E条滴定法、棋盘滴定法和生长曲线，对麦卢卡蜂蜜对MRSA和铜绿假单胞菌的亚致死浓度分别进行了15种抗生素的检测。五种新型抗生素和麦卢卡蜂蜜的组合被发现提高了体外抗菌效果，这些为未来局部治疗这两种重要病原体引起的伤口感染提供了新的途径。
Following the discovery of synergistic action between oxacillin and manuka honey against methicillin-resistant Staphylococcus aureus, this study was undertaken to search for further synergistic combinations of antibiotics and honey that might have potential in treating wounds. Fifteen antibiotics were tested with and without sublethal concentrations of manuka honey against each of MRSA and Pseudomonas aeruginosa using disc diffusion, broth dilution, E strip, chequerboard titration and growth curves. Five novel antibiotic and manuka honey combinations were found that improved antibacterial effectiveness in vitro and these offer a new avenue of future topical treatments for wound infections caused by these two important pathogens.