Computed tomographic features of adenoid cystic carcinoma in the palate
Computed tomographic features of adenoid cystic carcinoma in the palate
复制标题
腭腺样囊性癌的计算机断层扫描特征
DOI：
10.1186/s40644-019-0190-z
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发表时间：
2019-01
期刊：
影响因子：
4.9
通讯作者：
Zhong Lai-ping
中科院分区：
文献类型：
--
作者：
Ju Wu-tong;Zhao Tong-chao;Liu Ying;Tan Yi-ran;Dong Min-jun;Sun Qi;Wang Li-zhen;Li Jiang;Zhong Lai-ping
目的探讨腭部黏膜完整的腺样囊性癌（adenoid cystic carcinoma，ACC）的CT表现，建立临床诊断的预测模型。方法2016年3月至2018年5月，收集102例腭部黏膜完整的肿瘤患者，其中28例术后病理诊断为ACC。记录并分析患者的临床症状、CT表现及病理诊断。采用单因素分析和多因素Logistic回归分析确定ACC的独立预测因子，评价预测模型的判别和校正，并进行内部验证（P= 0.019）;腭骨破坏腭大孔（GPF）增大（P<0.001）;累及翼腭窝（P<0.001）、耳孔（P<0.001）、鼻腔（P<0.001）、上颌骨（P <0.001）、麻木（P= 0.007）、疼痛（P<0.001）。多因素Logistic回归分析显示，年龄和GPF增大是腭部肿瘤ACC的独立预测因素。诊断预测模型表现出良好的歧视和校准，评估的受试者工作特征曲线下的面积（0.98）和Hosmer-Lemeshow拟合优度检验（P= 0.927）。结论腭ACC预测模型的基础上年龄和GPF扩大显示良好的歧视，没有证据表明校准不良。腭部肿瘤和粘膜完整的老年患者，当他们有GPF增大时，应考虑ACC。
BackgroundTo evaluate the computed tomographic features and create a prediction model for clinical diagnosis of adenoid cystic carcinoma (ACC) in the palate with intact mucosa.MethodsFrom March 2016 to May 2018, 102 patients with palatal tumors and intact mucosa, including 28 patients with a pathological diagnosis of ACC after surgery, were enrolled in this study. The patients’ clinical symptoms, computed tomographic features and pathological diagnoses were recorded and analyzed. Independent predictors of ACC were determined by using univariate analysis and multivariate logistic regression, and the discrimination and calibration of the prediction model was evaluated, and internal validation was performed.ResultsUnivariate analysis of patients showed that ACC patients were more likely than non-ACC patients to be older (P= 0.019); to have palatine bone destruction (P<0.001) and greater palatine foramen (GPF) enlargement (P<0.001); to have involvement of the pterygopalatine fossa (P<0.001), foramen rotundum (P<0.001), nasal cavity (P<0.001) and maxillary bone (P<0.001); and to have numbness (P= 0.007) and pain (P<0.001). Multivariate logistic analysis showed that age and GPF enlargement were independent predictors of ACC in palatal tumors. The diagnostic prediction model showed good discrimination and calibration, as evaluated by the area under the receiver operating characteristic curve (0.98) and the Hosmer-Lemeshow goodness-of-fit test (P= 0.927).ConclusionsThe palate ACC prediction model based on age and GPF enlargement shows excellent discrimination with no evidence of poor calibration. Older patients with palatal tumors and intact mucosa should be considered for ACC when they have GPF enlargement.
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影响因子：
4.6
作者：
M. Al-Abbadi;Luaay Aziz
通讯作者：
M. Al-Abbadi;Luaay Aziz
DOI：
10.1002/lary.26228
发表时间：
2017-04
期刊：
The Laryngoscope
影响因子：
--
作者：
Chopra S;Kamdar DP;Cohen DS;Heilbrun LK;Smith D;Kim H;Lin HS;Jacobs JR;Yoo G
通讯作者：
Yoo G
影响因子：
2.3
作者：
A. A. Abdel Razek-A.;S. Mukherji
通讯作者：
A. A. Abdel Razek-A.;S. Mukherji
影响因子：
2.3
作者：
Razek, Ahmed Abdel Khalek Abdel;Mukherji, Suresh K.
通讯作者：
Mukherji, Suresh K.
DOI：
10.1016/j.bjoms.2016.03.023
发表时间：
2016-07
期刊：
The British journal of oral & maxillofacial surgery
影响因子：
--
作者：
R. Tabrizi;E. Aliabadi;M. Maleki;Mehrdad Dehghanpour Barouj
通讯作者：
R. Tabrizi;E. Aliabadi;M. Maleki;Mehrdad Dehghanpour Barouj