Prognostic significance of heat shock protein 105 in lung adenocarcinoma
Prognostic significance of heat shock protein 105 in lung adenocarcinoma
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DOI：
10.3892/mmr_00000144
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发表时间：
2009-07-01
影响因子：
3.4
通讯作者：
Okumura, Meinoshin
中科院分区：
文献类型：
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作者：
Oda, Tomofumi;Morii, Eiich;Okumura, Meinoshin
热休克蛋白105（HSP 105）在多种肿瘤中过表达，并且已知其保护细胞免受细胞毒性刺激。HSP 105在癌症中表达的预后意义尚未得到充分评估。在此，我们对116例肺腺癌患者（男性68例，女性48例，年龄38-81岁，中位数63岁）的HSP 105表达进行了免疫组化检测。肿瘤分期为I期64例，II期16例，III期36例。在非癌组织中，HSP 105在支气管的纤毛细胞中表达。肿瘤细胞呈HSP 105持续阳性，强度不同。每个病例中的HSP 105评分基于占据癌组织最宽区域的肿瘤细胞的染色强度确定如下：肿瘤细胞显示强度弱于支气管上皮、与支气管上皮相当和强于支气管上皮的病例被指定为1、2和3分，并分别编号为84、19和13例。HSP 105评分与复发率及疾病分期显著相关。单因素分析显示淋巴结转移、疾病分期和HSP 105评分为预后不良因素。多因素分析显示淋巴结转移和HSP 105评分是影响总生存期和无病生存期的独立预后因素。HSP 105表达有助于预测肺腺癌患者的预后。
Heat shock protein 105 (HSP105) is overexpressed in various tumors and is known to protect cells from cytotoxic stimuli. The prognostic significance of HSP105 expression in cancer has not been fully evaluated. Here, HSP105 expression in lung adenocarcinoma was immunohistochemically examined in 116 patients: 68 males and 48 females with ages ranging from 38-81 (median 63) years. Tumor stage was I in 64, II in 16 and III in 36 patients. In non-cancerous tissues, HSP105 was expressed in the ciliated cells of bronchi. Tumor cells were constantly positive for HSP105, with varying intensities. The HSP105 score in each case was determined based on the staining intensity of the tumor cells occupying the widest area of cancerous tissue as follows: cases with tumor cells showing an intensity weaker than, comparable to and stronger than the bronchial epithelium were assigned a score of 1, 2 and 3, and numbered 84, 19 and 13 cases, respectively. HSP105 score was significantly correlated with the rate of recurrence and the stage of the disease. Univariate analysis showed that lymph node metastasis, disease stage and HSP105 score were unfavorable prognostic factors. Multivariate analysis revealed that lymph node metastasis and HSP105 score were independent prognostic factors for overall and disease-free Survival. HSP105 expression is useful for the prediction of prognosis in patients with lung adenocarcinoma.