The effects of an intravenous bolus of dexmedetomidine following extubation in a mixed population of dogs undergoing general anaesthesia and surgery
The effects of an intravenous bolus of dexmedetomidine following extubation in a mixed population of dogs undergoing general anaesthesia and surgery
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DOI：
10.1016/j.tvjl.2014.01.015
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发表时间：
2014-04-01
影响因子：
2.2
通讯作者：
Murrell, Joanna C.
中科院分区：
文献类型：
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作者：
Hunt, James R.;Slingsby, Louisa S.;Murrell, Joanna C.
一项观察者盲法、安慰剂对照研究评价了62.5mug/m(2)右美托咪定静脉注射对犬异氟醚麻醉后苏醒的影响。研究对象是44只健康的狗，体重1.8-19.95公斤，接受手术，预计会引起轻微到中度的疼痛。所有患者均予125mU g/m(2)右美托咪定和20mU g/kg丁丙诺啡肌注。异丙酚诱导麻醉，异氟醚维持麻醉。适当应用非类固醇抗炎药和局麻药。拔管前立即给予右美托咪定62.5 mg/m(2)组(D组)或等量肝素化生理盐水(S组)。分别于用药前即刻、给药后20min、给药时(TO)、15~30min间隔4h(T240min)进行心率、呼吸频率、疼痛(简明格拉斯哥综合疼痛评分[SF-GCPS]、动态交互视觉模拟评分[DIVAS])、镇静评分(简易描述性评分[SDS]，DIVAS)和机械伤害性阈值(MNT)评定。康复质量评分0~3分(抑郁自评量表)。经t检验、Mann-Whitney U检验、双因素方差分析和Fisher‘s精确检验，D组不良质量恢复明显减少(D2[1-3]；S 2[0-3]；P=0.0001.0 2)，而D组镇静作用增加(P=0.0 5)。D组拔管后15~120min疼痛评分低于S组(P=0.001)，但拔管后前4h追加镇痛量两组间差异无统计学意义。右旋美托咪定可减少犬不良麻醉恢复的发生率。(C)2014爱思唯尔有限公司。保留所有权利。
An observer blinded, placebo controlled study evaluated the effects of 62.5 mu g/m(2) dexmedetomidine administered IV on recovery from isoflurane anaesthesia in dogs. Forty-four healthy dogs, weighing 1.8-19.95 kg, presented for surgery that was expected to cause mild to moderate pain were studied. All were premedicated with 125 mu g/m(2) dexmedetomidine and 20 mu g/kg buprenorphine IM. Anaesthesia was induced with propofol and maintained with isoflurane. Non-steroidal anti-inflammatory drugs and local anaesthetics were administered as appropriate. Immediately prior to extubation dogs were treated with dexmedetomidine 62.5 mu g/m(2) (group D) or an equivalent volume of heparinised saline (S). Assessments of heart rate, respiratory rate, pain (short form Glasgow composite pain scale [SF-GCPS], dynamic interactive visual analogue scale [DIVAS]), sedation (simple descriptive scale [SDS], DIVAS) and mechanical nociceptive threshold (MNT) were performed immediately before premedication, 20 min later, at the time of test drug administration (TO) and at 15-30 min intervals for four hours (T240 min). Recovery quality was scored 0 - 3 (SDS). Data were analysed with Student's t and Mann-Whitney U tests, two-way ANOVA and Fisher's exact test.Significantly fewer poor quality recoveries were observed in group D (D 2 [1-3]; S 2 [0-3]; P = 0.02), however, sedation was increased in group D compared to groups from T15 to T150 min (P = 0.0001). Pain scores were lower in group D compared to group S from T15 to T120 min (P = 0.001), but the requirement for additional analgesia in the first 4 h following extubation was not different between groups. Dexmedetomidine may decrease the incidence of poor quality anaesthetic recoveries in dogs. (C) 2014 Elsevier Ltd. All rights reserved.