Peripheral and cerebrovascular atherosclerotic disease in diabetes mellitus
Peripheral and cerebrovascular atherosclerotic disease in diabetes mellitus
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DOI：
10.1016/j.beem.2008.10.015
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发表时间：
2009-06-01
影响因子：
7.4
通讯作者：
Mukherjee, Debabrata
中科院分区：
文献类型：
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作者：
Mukherjee, Debabrata
糖尿病常与涉及冠状动脉、外周和脑血管循环的动脉粥样硬化性血管疾病相关。与非糖尿病患者相比，糖尿病患者的外周动脉疾病（PAD）更为弥漫，通常累及腘动脉和膝下动脉。与其他患有这种疾病的患者一样，患有PAD的糖尿病患者的治疗目标是积极治疗动脉粥样硬化风险因素，以减少未来的心血管事件以及改善跛行症状和预防肢体截肢。糖尿病还与中风的高风险相关，中风是糖尿病个体发病率和死亡率的常见原因。最佳的血压控制对于降低这些患者未来卒中的风险至关重要。临床医生需要意识到糖尿病和非冠状动脉粥样硬化之间的密切联系，并使用适当的药物和介入治疗，以减少这些患者的相关残疾和死亡率。(C)2008爱思唯尔有限公司保留所有权利。
Diabetes mellitus is frequently associated with atherosclerotic vascular disease involving the coronary, peripheral and cerebrovascular circulation. Compared with non-diabetic Counterparts, peripheral arterial disease (PAD) in diabetic individuals is more diffuse and often involves the popliteal and below-knee arteries. The goal of treatment in diabetic patients with PAD, as in other patients with this condition, is to aggressively treat atherosclerotic risk factors to reduce future cardiovascular events as well as to improve Symptoms Of claudication and prevent limb amputation. Diabetes is also associated with a heightened risk of stroke which is a common cause of morbidity and mortality in diabetic individuals. Optimal blood pressure control is paramount in reducing the future risk of stroke in these patients. Clinicians need to be aware of the strong association between diabetes and non-coronary atherosclerosis and use appropriate medical and interventional treatments to reduce the associated disability and mortality in these patients. (C) 2008 Elsevier Ltd. All rights reserved.