Cognitive function in idiopathic pulmonary fibrosis
Cognitive function in idiopathic pulmonary fibrosis
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DOI：
10.1177/1479972315603552
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发表时间：
2015-11-01
影响因子：
4.1
通讯作者：
Whelan, Timothy P. M.
中科院分区：
文献类型：
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作者：
Bors, Melinda;Tomic, Rade;Whelan, Timothy P. M.
本研究的目的是调查是否有证据表明，与肺健康的个体相比，患有严重特发性肺纤维化（IPF）的个体存在认知缺陷。被试完成了五项神经心理测试：Trail Making Test (TMT) A和B， Stroop Color Word Test (1,2,3), Hopkins Verbal Learning Test, Boston Naming Test, grooded pekboard Test，以及简表-36和Beck Depression Index。12名参与者（7名男性，平均年龄69.3岁，9.4岁）由一氧化碳扩散能力（DLCO） 30%定义为严重IPF组。参与研究的配偶（n = 15,4名男性）作为对照组，平均年龄为66.0岁，10.8岁。在性别和年龄的控制下，重度组的平均TMT B时间（69.4秒，135.9秒）明显长于轻度组和对照组（86.7秒vs 83.2秒，p分别= 0.004和0.008），表明在需要速度分散注意力的任务上表现较差。此外，在Stroop 3测试中，严重组正确识别颜色的数量明显较低（22.4 vs 30.6 vs 38.6; p < 0.001），这表明当需要抑制熟悉的反应时，处理速度较慢。重度IPF患者的认知功能比轻度IPF或对照组差。需要进一步的研究来解释这些发现，并制定针对这些缺陷的干预措施。
The purpose of this study was to investigate whether there is evidence that individuals with severe idiopathic pulmonary fibrosis (IPF) have cognitive deficits when compared to individuals with healthy lungs. Participants completed five neuropsychological tests: Trail Making Test (TMT) A and B, Stroop Color Word Test (1, 2, 3), Hopkins Verbal Learning Test, Boston Naming Test, and Grooved Pegboard Test, additionally, the short form-36 and Beck Depression Index. Twelve participants (7 male, mean age 69.3, 9.4 years) comprised the severe IPF group defined by a diffusion capacity for carbon monoxide (DLCO) 30%. Participating spouses (n = 15, 4 male) served as the control group and had a mean age of 66.0, 10.8 years. Controlling for gender and age, the severe group had a significantly longer mean TMT B time (69.4, 135.9 seconds) than the mild group and the control group (86.7 seconds vs 83.2 seconds; p = 0.004 and 0.008 respectively), suggesting inferior performance on tasks requiring speed divided attention. In addition, the severe group had a significantly lower number of correctly identified colors in the Stroop 3 test (22.4 vs 30.6 vs 38.6; p < 0.001), suggesting slower processing speeds when requiring suppression of a familiar response. Participants with severe IPF had worse cognitive function than mild IPF or control subjects. Further research is needed to explain these findings and to develop interventions tailored to address these deficits.