Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
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DOI：
10.1242/dev.027805
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发表时间：
2009-03-01
期刊：
影响因子：
4.6
通讯作者：
Kreidberg, Jordan A.
中科院分区：
文献类型：
--
作者：
Liu, Yingjie;Chattopadhyay, Nibedita;Kreidberg, Jordan A.
细胞外基质的整联蛋白受体和受体酪氨酸激酶生长因子受体代表将周围环境信息转导到细胞中的两个主要受体家族。 Wnt 蛋白是调节形态发生事件的信号分子的主要家族。目前对于 Wnt 基因本身的表达是如何调节的了解甚少。在这项研究中，我们证明α3β1整合素（参与肾脏发育的主要层粘连蛋白受体）和c-Met（肝细胞生长因子受体）协调发出信号以调节小鼠中Wnt7b的表达。 Wnt 信号反过来似乎可以调节发育中肾脏乳头中的上皮细胞存活，从而使上皮小管伸长形成成熟的乳头。总之，这些结果证明了如何整合来自整合素和生长因子受体的信号来调节重要信号分子家族的表达，从而调节形态发生事件。
Integrin receptors for the extracellular matrix and receptor tyrosine kinase growth factor receptors represent two of the major families of receptors that transduce into cells information about the surrounding environment. Wnt proteins are a major family of signaling molecules that regulate morphogenetic events. There is presently little understanding of how the expression of Wnt genes themselves is regulated. In this study, we demonstrate that alpha 3 beta 1 integrin, a major laminin receptor involved in the development of the kidney, and c-Met, the receptor for hepatocyte growth factor, signal coordinately to regulate the expression of Wnt7b in the mouse. Wnt signals in turn appear to regulate epithelial cell survival in the papilla of the developing kidney, allowing for the elongation of epithelial tubules to form a mature papilla. Together, these results demonstrate how signals from integrins and growth factor receptors can be integrated to regulate the expression of an important family of signaling molecules so as to regulate morphogenetic events.