Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses.
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses.
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DOI：
10.1016/j.cell.2012.02.050
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发表时间：
2012-04-13
期刊：
影响因子：
64.5
通讯作者：
Ruvkun G
中科院分区：
文献类型：
--
作者：
Melo JA;Ruvkun G
秀丽隐杆线虫消耗大肠杆菌等良性细菌，并被病原体和毒素排斥。在这里，我们展示了RNAi和毒素介导的核心细胞活动的破坏，包括翻译、呼吸和蛋白质周转，刺激了对吸引的大肠杆菌的行为回避。这些基本过程的RNAi在没有毒素或病原体的情况下也诱导解毒和先天免疫反应基因的表达。破坏非神经元组织的核心过程可以刺激厌恶行为，揭示神经内分泌轴的控制。微生物避免需要血清素能和Jnk激酶信号。我们建议监视途径监督关键的细胞活动以检测病原体，其中许多病原体部署毒素和毒力因子来破坏这些相同的宿主途径。由过去的毒素或微生物相互作用选择的控制行为、解毒和免疫的细胞监视和内分泌通路的变化可能是对食物、药物和微生物的异常反应的基础。
The nematode C. elegans consumes benign bacteria such as E. coli and is repelled by pathogens and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities, including translation, respiration, and protein turnover, stimulates behavioral avoidance of attractive E. coli. RNAi of such essential processes also induces expression of detoxification and innate immune response genes in the absence of toxins or pathogens. Disruption of core processes in non-neuronal tissues can stimulate aversion behavior, revealing a neuroendocrine axis of control. Microbial avoidance requires serotonergic and Jnk kinase signaling. We propose that surveillance pathways oversee critical cellular activities to detect pathogens, many of which deploy toxins and virulence factors to disrupt these same host pathways. Variation in cellular surveillance and endocrine pathways controlling behavior, detoxification and immunity selected by past toxin or microbial interactions could underlie aberrant responses to foods, medicines, and microbes.
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影响因子：
30.3
作者：
McEwan DL;Kirienko NV;Ausubel FM
通讯作者：
Ausubel FM
影响因子：
2.7
作者：
Fukushige, T;Hawkins, MG;McGhee, JD
通讯作者：
McGhee, JD
DOI：
10.1073/pnas.0602987103
发表时间：
2006-08-08
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
7
作者：
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通讯作者：
Hodgkin, Jonathan
影响因子：
4
作者：
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通讯作者：
Ron, David