ACUTE TOXICITY OF COMBINATIONS OF SODIUM DICHROMATE, SODIUM ARSENATE AND COPPER-SULFATE IN THE RAT
ACUTE TOXICITY OF COMBINATIONS OF SODIUM DICHROMATE, SODIUM ARSENATE AND COPPER-SULFATE IN THE RAT
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DOI：
10.1016/0742-8413(89)90021-2
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发表时间：
1989-01-01
影响因子：
3.9
通讯作者：
EDWARDS, IR
中科院分区：
文献类型：
--
作者：
MASON, RW;EDWARDS, IR
1.给成年雄性Wistar大鼠腹腔注射低剂量重铬酸钠(5 mg/kg)、砷酸钠(25 mg/kg)和硫酸铜(5.9 mg/kg)的不同组合，可抵消各化合物固有的急性毒性。2.一种或多种受试化合物与高剂量重铬酸钠(35 mg/kg)、高剂量砷酸钠(90 mg/kg)或硫酸铜(23.5 mg/kg)共用时，急性毒性显著高于高剂量重铬酸盐、砷酸盐或Cu2+单独给药。
1. The intraperitoneal treatment of adult male Wistar rats with various combinations of low doses of sodium dichromate (5 mg/kg), sodium arsenate (25 mg/kg) and copper sulphate (5.9 mg/kg) tended to counteract the inherent acute toxicity of each compound. 2. The co-administration of low doses of one or more of the test compounds with a high dose of sodium dichromate (35 mg/kg), sodium arsenate (90 mg/kg) or copper sulphate (23.5 mg/kg) resulted in a significant increase in acute toxicity in comparison with that produced by the administration of high doses of dichromate, arsenate or Cu2+ alone.