Microphase separation of smart double-responsive copolymer microgels studied by local fluorescence probes
Microphase separation of smart double-responsive copolymer microgels studied by local fluorescence probes
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DOI：
10.1016/j.polymer.2017.07.074
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发表时间：
2017-09-08
期刊：
影响因子：
4.6
通讯作者：
Hellweg, Thomas
中科院分区：
文献类型：
--
作者：
Braendel, Timo;Wiehemeier, Lars;Hellweg, Thomas
本研究重点研究含有不同浓度丙烯酸的N-异丙基丙烯酰胺（NIPAM）和丙烯酸（AAc）共聚物微凝胶的溶胀行为。如果使用“经典”佩尔顿合成方法，则通过傅里叶变换红外（FT-IR）光谱研究共聚单体的掺入，并找到共聚单体的掺入阈值。使用芘作为荧光探针，通过光子相关光谱（PCS）和荧光光谱分析这些微凝胶的溶胀情况。 PCS无法检测标称丙烯酸含量为10mol%和15mol%的共聚物微凝胶的消溶胀情况。然而，在荧光测量中，仍然可以观察到 PNIPAM 相变。造成这种差异的原因是丙烯酸在共聚物微凝胶中的不均匀分布，这使得它们成为药物输送和靶向应用的有希望的候选者。 (C) 2017 Elsevier Ltd. 保留所有权利。
The present study focuses on the swelling behavior of copolymer microgels of N-isopropylacrylamide (NIPAM) and acrylic acid (AAc) containing different concentrations of acrylic acid. The incorporation of the comonomer is investigated by Fourier transform infrared (FT-IR) spectroscopy and an incorporation threshold value for the comonomer is found, if the "classical" Pelton synthesis approach is used. The swelling of these microgels is analyzed by photon correlation spectroscopy (PCS) and fluorescence spectroscopy, using pyrene as a fluorescent probe. The deswelling of copolymer microgels with 10mol% and 15mol% nominal acrylic acid content can not be detected by PCS. However, in fluorescence measurements the PNIPAM phase transition is still observable. The reason for this difference is a non-uniform distribution of acrylic acid in the copolymer microgels, which makes them promising candidates for drug-delivery and - targeting applications. (C) 2017 Elsevier Ltd. All rights reserved.