Human leukocyte antigen class I antigen expression is an independent prognostic factor in ovarian cancer
Human leukocyte antigen class I antigen expression is an independent prognostic factor in ovarian cancer
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DOI：
10.1158/1078-0432.ccr-06-2087
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发表时间：
2007-06-15
影响因子：
11.5
通讯作者：
Spendlove, Ian
中科院分区：
文献类型：
--
作者：
Rolland, Phil;Deen, Suha;Spendlove, Ian
目的：尽管在癌症治疗方面取得了进展，但卵巢癌的预后仍然很低，并且传统的病理标准不能完全预测。独立于这些标准预测预后的生物标志物揭示了重要的分子变异，有助于新疗法的开发和靶向。以前的工作表明，人类白细胞抗原（HLA）I类抗原的表达是独立的预测预后的结直肠癌和乳腺癌。我们研究了一个大系列的卵巢cancer.Experimental Designs的HLA I类抗原表达的预后潜力：339例卵巢癌的组织芯片连接到前瞻性记录的临床病理和随访数据构建。按照HLA I类重链（HC-10）和β（2）-微球蛋白（β（2）-m）的标准免疫组织化学方案对其进行染色。使用Pearson卡方检验、Kaplan-Meier曲线和对数秩检验比较HLA I类抗原表达与临床病理因素和总体疾病特异性生存率。结果：HLA I类抗原表达与临床病理因素无单因素相关性。单变量分析中HC-10（+）/beta（2）-m（+）表型偏离与生存率降低相关（对数秩检验，5.69; P = 0.017）;多变量分析显示，保留的HC-10（+）/β（2）-m（+）表型预测预后改善，与年龄、分期、细胞减灭水平和化疗使用无关结论：HLA-I类抗体表达是卵巢癌独立的预后指标，其缺失与预后不良相关。
Purpose: Despite improvements in cancer treatment, the prognosis of ovarian cancer remains low and imperfectly predicted by traditional pathologic criteria. Biomarkers that predict prognosis independently of such criteria shed light on important molecular variations, aiding in the development and targeting of novel therapies. Previous work has shown human leukocyte antigen (HLA) class I antigen expression to be independently predictive of prognosis in colorectal and breast cancer. We investigated the prognostic potential of HLA class I antigen expression by studying a large series of ovarian cancers.Experimental Design: A tissue microarray of 339 ovarian cancer cases linked to prospectively recorded clinicopathologic and follow-up data was constructed. This was stained following a standard immunohistochemical protocol for HLA class I heavy chain (HC-10) and beta(2)-microglobulin (beta(2)-m). HLA class I antigen expression was compared with clinicopathologic factors and overall disease-specific survival using the Pearson chi(2) test, Kaplan-Meier curves, and the log-rank test. Cox regression was used to test for the independence and magnitude of effects.Results: There were no univariate correlations between HLA class I antigen expression and clinicopathologic factors. Deviation from an HC-10(+)/beta(2)-m(+) phenotype correlated with reduced survival in univariate analysis (log-rank, 5.69; P = 0.017); a retained HC-10(+)/beta(2)-m(+) phenotype predicted improved prognosis independently of age, stage, level of cytoreduction, and chemotherapy usage on multivariate analysis (hazard ratio, 0.587; 95% confidence interval, 0.442-0.781; P < 0.001).Conclusions: HLA class I anti en expression is an independent prognostic marker in ovarian cancer, its loss correlating with a poor prognostic outcome.