Prognostic significance of intratumoural microvessel density (IMD) in resected pancreatic and ampullary cancers to standard histopathological variables and survival
Prognostic significance of intratumoural microvessel density (IMD) in resected pancreatic and ampullary cancers to standard histopathological variables and survival
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DOI：
10.1053/ejso.2002.1307
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发表时间：
2002-09-01
期刊：
影响因子：
--
通讯作者：
Davidson, BR
中科院分区：
文献类型：
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作者：
Khan, AW;Dhillon, AP;Davidson, BR
目的：肿瘤生长需要血管生成。通过瘤内微血管密度（IMID）进行的评估对于许多实体瘤具有预后意义。关于其在胰腺癌中的使用存在争议，并且对其在壶腹肿瘤中的作用知之甚少。目的是研究 IMID 作为胰头导管腺癌和壶腹区癌症切除后的预后标志物。 方法：对 47 名在潜在治愈性 (R0/R1) 切除术后幸存的患者（23 名胰腺癌和 24 名壶腹癌，平均年龄 62.0 岁）进行分析。对这些肿瘤的石蜡包埋切片进行 CD-34 免疫组织化学染色，并测定 IMID（放大倍数 x200）。使用 Cox 多变量分析，这与组织病理学数据和生存率相关。结果：胰腺癌组的平均生存期为 18.4 个月 (SE = 2.7)，壶腹癌组的平均生存期为 81.2 个月 (SE = 9.9)。在胰腺癌组中，多变量分析发现 IMID 对生存具有独立的预后意义（P = 0.002，风险比 (HR) 13.60）以及显微镜下切缘受累（P = 0.003，HR 15.18）。对于壶腹癌，有淋巴结转移的患者的 IMID 较高（P=0.02，Mann-Whitney U 检验）。结论：切除的胰腺癌中的 IMID 与生存相关。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
Aim: Angiogenesis is required for tumour growth. Its evaluation, by intratumoural microvessel density (IMID), has prognostic significance in many solid tumours. There is controversy regarding its use in pancreatic cancer and little is known about its role in ampullary tumours. The aim is to study IMID as a prognostic marker in resected ductal adenocarcinomas of head of pancreas and cancers of the ampullary region.Methods: Forty-seven patients (23 pancreatic and 24 ampullary, mean age 62.0 years) surviving a potentially curative (R0/R1) resection were analysed. Paraffin-embedded sections of these tumours were immunohistochemically stained for CD-34 and IMID was determined (magnification x200). This was correlated with histopathological data and survival using Cox's multivariate analysis.Results: Mean survival for the pancreatic cancer group was 18.4 months (SE = 2.7) and 81.2 months (SE = 9.9) for the ampullary cancer group. In the pancreatic cancer group, IMID was found to have independent prognostic significance to survival on multivariate analysis (P = 0.002, Hazard Ratio (HR) 13.60) along with microscopic resection margin involvement (P=0.003, HR 15.18). For ampullary cancers, IMID was higher in those with lymph node metastasis (P=0.02, Mann-Whitney U-test).Conclusion: IMID in resected pancreatic cancers correlates with survival. (C) 2002 Elsevier Science Ltd. All rights reserved.