LAMININ RECEPTORS - ACHIEVING SPECIFICITY THROUGH COOPERATION
LAMININ RECEPTORS - ACHIEVING SPECIFICITY THROUGH COOPERATION
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DOI：
10.1016/s0962-8924(00)89100-x
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发表时间：
1995-11-01
影响因子：
19
通讯作者：
MERCURIO, AM
中科院分区：
文献类型：
--
作者：
MERCURIO, AM
层粘连蛋白是细胞外基质蛋白的一个大家族，可以深刻地影响发育、分化和疾病进展。层粘连蛋白的生物学效应是由连接层粘连蛋白基质和细胞内信号通路的表面受体介导的。包括整合素和其他分子在内的几类受体可能协同作用，为各种层粘连蛋白介导的现象提供明显的特异性。这篇综述评估了我们目前对层粘连蛋白受体的理解，并讨论了这些受体如何识别层粘连蛋白之间的结构差异，并将这些差异传递给细胞。
The laminins are a large family of extracellular matrix proteins that can profoundly influence development, differentiation and disease progression. The biological effects of the laminins are mediated by surface receptors that link laminin matrices to intracellular signalling pathways. Several classes of receptors, including integrins and other molecules, may cooperate to provide the specificity apparent irt the diverse array of laminin-mediated phenomena. This review assesses our current understanding of laminin receptors and discusses how such receptors could recognize structural differences among the laminins and relay these differences to the cell.