Calmodulin point mutations affect Drosophila development and behavior.
Calmodulin point mutations affect Drosophila development and behavior.
复制标题
钙调蛋白点突变影响果蝇的发育和行为。
DOI：
10.1093/genetics/147.4.1783
复制
发表时间：
1997
期刊：
影响因子：
3.3
通讯作者：
Beckingham,K
中科院分区：
文献类型：
--
作者：
Nelson,HB;Heiman,RG;Bolduc,C;Kovalick,GE;Whitley,P;Stern,M;Beckingham,K
Calmodulin (CAM) is recognized as a major intermediary in intracellular calcium signaling, but as yet little is known of its role in developmental and behavioral processes. We have generated and studied mutations to the endogenousCamgene ofDrosophila melanogasterthat change single amino acids within the protein coding region. One of these mutations produces a striking pupal lethal phenotype involving failure of head eversion. Various mutant combinations produce specific patterns of ectopic wing vein formation or melanotic scabs on the cuticle. Anaphase chromosome bridging is also seen as a maternal effect during the early embryonic nuclear divisions. In addition, specific behavioral defects such as poor climbing and flightlessness are detected among these mutants. Comparisons with other Drosophila mutant phenotypes suggests potentialCAMtargets that may mediate these developmental and behavioral effects, and analysis of theCAMcrystal structure suggests the structural consequences of the individual mutations.
