From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal
From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal
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DOI：
10.1530/erc-17-0004
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发表时间：
2017-04-01
影响因子：
3.9
通讯作者：
Trouillas, J.
中科院分区：
文献类型：
--
作者：
Asa, S. L.;Casar-Borota, O.;Trouillas, J.
腺垂体细胞肿瘤的分类具有误导性，因为腺瘤和癌之间的区分过于简单，仅基于转移扩散，基于有丝分裂检测或Ki-67或p53表达来定义非典型腺瘤的可重复性和预测价值较差。此外，目前垂体前叶肿瘤的分类并不能准确反映临床行为谱。增殖性病变的侵袭和再生以及激素高分泌的持续导致显著的发病率和死亡率。我们提出一个新的术语，垂体神经内分泌肿瘤（PitNET），这是一致的，用于其他神经内分泌肿瘤，并认识到这些肿瘤对患者的高度可变的影响。
The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.