Melanoma-infiltrating dendritic cells: Limitations and opportunities of mouse models.
Melanoma-infiltrating dendritic cells: Limitations and opportunities of mouse models.
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DOI：
10.4161/onci.22660
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发表时间：
2012-12-01
期刊：
影响因子：
7.2
通讯作者：
Janssen EM
中科院分区：
文献类型：
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作者：
Klarquist JS;Janssen EM
树突状细胞（DCs）对黑色素瘤的浸润具有致瘤作用，它具有诱导肿瘤耐受、促进血管生成和转移的能力。然而，也已经显示肿瘤浸润DC（TIDCs）诱导抗肿瘤应答，因此可以在成本有效的治疗方法中靶向以获得呈递相关肿瘤抗原的患者特异性DC，而不需要离体DC扩增或肿瘤抗原鉴定。不幸的是，很少有人知道的组成，性质和功能的TIDCs中发现的人黑色素瘤。小鼠黑色素瘤模型的建立极大地促进了对小鼠黑色素瘤免疫学的分子理解，但关于TIDCs的许多问题仍然没有答案。在这里，我们讨论了目前的知识黑色素瘤TIDCs在各种小鼠模型方面的翻译潜力和临床意义。
The infiltration of melanoma lesions by dendritic cells (DCs) has been suggested to play a tumorigenic role due to the capacity of DCs to induce tumor tolerance and promote angiogenesis as well as metastasis. However, it has also been shown that tumor-infiltrating DCs (TIDCs) induce antitumor responses and hence may be targeted in cost-effective therapeutic approaches to obtain patient-specific DCs that present relevant tumor antigens, without the need for ex vivo DC expansion or tumor antigen identification. Unfortunately, little is known about the composition, nature and function of TIDCs found in human melanoma. The development of mouse melanoma models has greatly contributed to the molecular understanding of melanoma immunology in mice, but many questions on TIDCs remain unanswered. Here, we discuss current knowledge about melanoma TIDCs in various mouse models with regard to their translational potential and clinical relevance.