Thoracic duct scintigraphy by orally administered I-123BMIPP - Normal findings and a case report
Thoracic duct scintigraphy by orally administered I-123BMIPP - Normal findings and a case report
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DOI：
10.1097/00003072-200110000-00008
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发表时间：
2001-10-01
影响因子：
10.6
通讯作者：
Fukuda, H
中科院分区：
文献类型：
--
作者：
Qureshy, A;Kubota, K;Fukuda, H
目的：探讨使用口服碘-123标记的15-（4-碘苯基）-3（R，S）-甲基-十五烷酸（I-123 BMIPP）的正常和病理状态下的胸导管成像，并研究示踪剂的分布和动力学在健康participators.Methods：放射性示踪剂管理与固体（在三个健康人和一个病人）或液体膳食（在其他三个健康人）。固体食物比液体食物含有更多的脂肪。获取图像以追踪放射性示踪剂从肠经由淋巴途径到体静脉循环的通路。在前视图和后视图中采集多个静态平面图像。血液样本进行了分析放射性和血清甘油三酯levels.Results：在健康的参与者，I-123 BMIPP从肠道吸收，并通过胸导管到达静脉循环。所有健康人在80分钟内成功地可视化了导管的胸部部分。放射性示踪剂动力学根据给予的膳食类型而变化。患者出现乳糜囊肿和右侧乳糜胸，并接受了胸导管结扎术。在患者中，观察到侧支淋巴管明显淤滞，乳糜漏入纵膈腔和右侧胸膜腔。示踪剂进入全身静脉循环延迟。一个正常的胸导管是没有看到在这个patient.Conclusions：闪烁摄影口服I-123 BMIPP是一种简单的方法来成像的胸导管和监测其病变。脂肪含量较高的膳食导致BMIPP吸收更好，可用作标准方法。
Purpose: To investigate the use of orally administered iodine-123-labeled 15-(4-iodophenyl)-3(R,S)-methyl-pentadecanoic acid (I-123 BMIPP) for thoracic duct imaging in normal and pathologic states and to study the tracer distribution and dynamics in healthy participants.Methods: The radiotracer was administered with solid (in three healthy persons and one patient) or liquid meals (in three other healthy persons). Solid meals contained relatively more fat content than did the liquid meal. Images were acquired to trace the passage of radiotracer from the intestine to the systemic venous circulation via the lymphatic route. Multiple static planar images were acquired in the anterior and posterior views. Blood samples were analyzed for radioactivity and serum triglyceride levels.Results: In the healthy participants, I-123 BMIPP was absorbed from the intestine and reached the venous circulation through the thoracic duct. The thoracic part of the duct was visualized successfully in all healthy persons within 80 minutes. The radiotracer dynamics varied according to the type of meal administered. The patient had chylomediastinum and right chylothorax and underwent thoracic duct ligation. In the patient, marked stasis in the collateral lymphatic channels was seen, as was chylous leakage into the mediastinal space and right pleural cavity. Passage of tracer to the general venous circulation was delayed. A normal thoracic duct was not seen in this patient.Conclusions: Scintigraphy by orally administered I-123 BMIPP is a simple method to image the thoracic duct and to monitor its lesions. Meals with a higher fat content result in better BMIPP absorption and may be used as a standard method.