Intrinsic and extrinsic negative regulators of nuclear protein transport processes.
Intrinsic and extrinsic negative regulators of nuclear protein transport processes.
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DOI：
10.1111/j.1365-2443.2012.01609.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Yoneda Y
中科院分区：
文献类型：
--
作者：
Sekimoto T;Yoneda Y
核-细胞质蛋白转运是细胞事件中的关键过程。运输信号（核定位信号和核输出信号）及其受体的识别促进了我们对这个不断扩展的领域的理解。当细胞核需要蛋白质的功能时，必须适当调节核运输，以通过核孔输送蛋白质；当细胞核不需要蛋白质时，将它们输出到细胞质中。在应激细胞中观察到核运输过程发生改变，这会改变基因表达。一些病毒干扰宿主细胞的核运输以逃避免疫防御。此外，某些转运因子对细胞内的核蛋白转运有负调节作用。了解核-细胞质运输的调节机制不仅提供有关细胞过程的重要信息，而且还有助于开发运输途径的特异性抑制剂。
The nuclear–cytoplasmic protein transport is a critical process in cellular events. The identification of transport signals (nuclear localization signal and nuclear export signal) and their receptors has facilitated our understanding of this expanding field. Nuclear transport must be appropriately regulated to deliver proteins through the nuclear pore when their functions are required in the nucleus, and to export them into the cytoplasm when they are not needed in the nucleus. Altered nuclear transport processes have been observed in stressed cells, which would change gene expressions. Some viruses interfere with nuclear transport in host cells to evade immune defense. Moreover, certain transport factors negatively regulate nuclear protein transport in cells. Understanding the regulatory mechanisms of nuclear–cytoplasmic trafficking not only provides important information about cellular processes, but also is of use for developing specific inhibitors for transport pathways.
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影响因子：
64.5
作者：
Fornerod, M;Ohno, M;Mattaj, IW
通讯作者：
Mattaj, IW
影响因子：
5.4
作者：
Kash, JC;Mühlberger, E;Katze, MG
通讯作者：
Katze, MG
DOI：
10.1073/pnas.220398297
发表时间：
2000-10-24
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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影响因子：
3.7
作者：
Flint, SJ;Huang, WY;Kyin, S
通讯作者：
Kyin, S