Elevation of serum macrophage colony-stimulating factor before the clinical manifestations of preeclampsia
Elevation of serum macrophage colony-stimulating factor before the clinical manifestations of preeclampsia
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DOI：
10.1067/s0002-9378(03)00674-4
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发表时间：
2003-11-01
影响因子：
9.8
通讯作者：
Inaba, N
中科院分区：
文献类型：
--
作者：
Hayashi, M;Ohkura, T;Inaba, N
目的：探讨血清巨噬细胞集落刺激因子(M-CSF)水平升高是否先于子痫前期。研究设计：我们选择了146例妇女，其中36例为非妊娠妇女参与初步研究，110例为妊娠18周左右单胎妊娠的正常血压孕妇。采集血液，并将血清保存在-20℃下，直到化验。16名妇女在妊娠后期发展为先兆子痫(先兆子痫)，而89名妇女继续正常妊娠直到分娩。选择年龄和产次相匹配的89名正常血压妊娠妇女中的35名作为对照组(对照组)。结果：子痫前期组血清M-CSF中位数为1295U/mL，对照组为957U/mL。子痫前期患者血清M-CSF水平明显高于对照组(P<0.0001)。结论：子痫前期患者血清M-CSF水平的升高明显先于临床表现的发展。血清M-CSF升高支持胎盘M-CSF升高。妊娠18周时的这种升高可能与胎盘缺氧有关，胎盘缺氧被认为是先兆子痫的原因。
OBJECTIVE: The purpose of this study was to determine whether the increase in serum macrophage colony stimulating factor (M-CSF) levels preceded the onset of preeclampsia.STUDY DESIGN: We selected 146 women, of whom 36 were nonpregnant women participating in the preliminary study and 110 were normotensive pregnant women at risk for preeclampsia who were carrying single fetuses at about 18 weeks of gestation. The blood was collected and serum was stored at -20degreesC until assay. Sixteen women had preeclampsia develop at a later stage of pregnancy (preeclamptics), whereas 89 women continued to have normotensive pregnancies until delivery. Thirty-five of the 89 women with normotensive pregnancy who were matched for age and parity were selected to form a control group (controls). Serum M-CSF levels were determined by the sandwich enzyme-linking immunosorbent assay method with use of three antibodies.RESULTS: Serum level of M-CSF was 1295 U/mL (median) in preeclamptics and 957 U/mL in controls. Serum M-CSF levels were significantly higher (P < .0001) in preeclamptics than in controls.CONCLUSION: The increase in serum M-CSF levels markedly precedes the development of clinical manifestations of preeclampsia. Elevation of serum M-CSF supports M-CSF elevation in the placenta. This elevation at 18 weeks of gestation may be related to placental hypoxia, which is considered the cause of preeclampsia.