Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
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DOI：
10.1016/j.bbaexp.2005.11.005
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发表时间：
2005-12-30
期刊：
影响因子：
--
通讯作者：
Büchler, C
中科院分区：
文献类型：
--
作者：
Schäffler, A;Neumeier, A;Büchler, C
基因组结构，启动子区，氨基酸序列和外显子特异性引物组合的人网膜蛋白基因。慢性炎症性肠病如克罗恩病患者网膜脂肪组织探针间网膜蛋白mRNA表达不同序列比较显示网膜素与人intelectin的同源性为100%。基于此，网膜素可能是一种新的脂肪细胞因子，在克罗恩病的背景下，在抵抗肠道细菌移位中发挥作用。(c)2005 Elsevier B.V.保留所有权利。
Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissue probes from patients with chronic inflammatory bowel diseases such as Crohn's disease. Sequence comparisons revealed a 100% identity of omentin with human intelectin. Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease. (c) 2005 Elsevier B.V. All rights reserved.