Effects of dopamine and kappa opioid receptors on fetal responsiveness to perioral stimuli.
Effects of dopamine and kappa opioid receptors on fetal responsiveness to perioral stimuli.
复制标题
多巴胺和卡帕阿片受体对胎儿对口周刺激反应的影响。
DOI：
10.1002/dev.420260104
复制
发表时间：
1993
影响因子：
2.2
通讯作者：
Smotherman,WP
中科院分区：
文献类型：
--
作者：
Robinson,SR;Moody,CA;Spear,LP;Smotherman,WP
作用于多巴胺能通路的阿片配体或药物会影响近期大鼠胚胎运动行为的变化。本研究采用选择性操作kappa阿片受体和D1DA受体的方法，研究了阿片和多巴胺参与调节牛奶冲泡的行为效应。牛奶减少了胎儿面部擦拭对触觉探针的反应，这种作用被kappa拮抗剂Nor-binaltorphimine和D1拮抗剂SCH-23390阻断。给予Kappa激动剂U50,488或D1激动剂SKF-38393的效果与牛奶相似，并在没有牛奶输注的情况下降低了胎儿对探针的反应。给予Nor-binaltorphimine可逆转SKF-38393的作用，并导致高发生率的擦拭反应。然而，SCH-23390的应用并不能逆转U50,488引起的面部擦拭的低发生率。这些发现表明，牛奶调节多巴胺受体的活性，进而促进阿片系统的kappa受体的活性，从而导致胎鼠皮肤反应性的变化。©1993 Johan Wiley&Sons，Inc.
Opioid ligands or drugs that act on dopaminergic pathways effect changes in the motor behavior of near‐term rat fetuses. In this study, selective manipulation of kappa opioid and D1 DA receptors was used to investigate opioid and dopamine involvement in mediating the behavioral effects of milk infusion. Milk reduced expression of the fetal facial wiping response to a tactile probe, and this effect was blocked by the kappa antagonist nor‐binaltorphimine as well as the D1 antagonist SCH‐23390. Administration of either the kappa agonist U50,488 or the D1 agonist SKF‐38393 mimicked the effects of milk and reduced fetal responsiveness to the probe in the absence of milk infusion. Administration of nor‐binaltorphimine reversed the effects of SKF‐38393 and resulted in a high incidence of the wiping response. However, administration of SCH‐23390 did not reverse the low incidence of facial wiping induced by U50,488. These findings suggest that milk modulates activity at dopamine receptors, which in turn promotes activity at kappa receptors of the opioid system to bring about changes in cutaneous responsiveness in the fetal rat. © 1993 Johan Wiley & Sons, Inc.