Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype
Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype
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DOI：
10.1373/49.2.295
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发表时间：
2003-02-01
影响因子：
9.3
通讯作者：
McDowell, IFW
中科院分区：
文献类型：
--
作者：
Moat, SJ;Ashfield-Watt, PAL;McDowell, IFW
Background. Riboflavin (vitamin B-2) is the precursor for FAD, the cofactor for methylenetetrahydrofolate reductase (MTHFR). MTHFR catalyzes the formation of 5-methyltetrahydrofolate, which acts as a methyl donor for homocysteine remethylation. Individuals with the MTHFR 677C-->T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status. It has been proposed that riboflavin may act together with folate to lower plasma tHcy, particularly in individuals with the thermolabile MTHFR T variant.Methods: We measured B-vitamin status and plasma tHcy in 126 healthy individuals 20-63 years of age (42 CC, 42 CT, and 42 TT MTHFR genotypes) at baseline and after three interventions (4 months): placebo plus natural diet; daily 400 mug folic acid supplement plus natural diet; and increased dietary folate to 400 mug/day.Results: At baseline and after nutritional intervention, lower riboflavin status was associated with increased plasma tHcy concentrations. Plasma tHcy was 2.6 mumol/L higher in the lowest plasma riboflavin quartile compared with the highest (P
