Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids
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DOI：
10.1126/science.285.5431.1276
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发表时间：
1999-08-20
期刊：
影响因子：
56.9
通讯作者：
Liao, JK
中科院分区：
文献类型：
--
作者：
Node, K;Huo, YQ;Liao, JK
环氧二十碳三烯酸（epoxyeicosatrienoicacids，EAF）是细胞色素P450环氧酶的产物，具有与内皮源性超极化因子相似的血管舒张作用。细胞色素P450亚型CYP 2 J2被克隆，并被鉴定为人内皮细胞中雌二醇的潜在来源。生理浓度的Eclase或CYP 2 J2过表达降低了精氨酸诱导的内皮细胞粘附分子表达，Eclase通过抑制转录因子NF-κ B和I κ B激酶的机制阻止了白细胞粘附到血管壁。的抑制作用的Ehrs是独立的膜超极化效应，这表明这些分子在血管炎症中发挥重要的非血管舒张作用。
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxy-genases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-kappa B and I kappa B kinase. The inhibitory effects of EETs were independent of their membrane-hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.