NMR reaction monitoring in flow synthesis.
NMR reaction monitoring in flow synthesis.
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DOI：
10.3762/bjoc.13.31
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发表时间：
2017
影响因子：
2.7
通讯作者：
de la Hoz A
中科院分区：
文献类型：
--
作者：
Gomez MV;de la Hoz A
介绍了使用流动化学进行核磁共振在线分析的最新进展。回顾了宏反应器和微反应器的使用，以及涉及微线圈的标准和定制 NMR 探针，并纳入高分辨率和台式 NMR 仪器。收集了一些最近选定的应用，包括合成应用、动力学和热力学参数的确定以及反应优化，甚至在单个实验和μL规模上也是如此。最后，讨论了允许自动反应监控和优化的软件。
Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and benchtop NMR instruments is reviewed. Some recent selected applications have been collected, including synthetic applications, the determination of the kinetic and thermodynamic parameters and reaction optimization, even in single experiments and on the μL scale. Finally, software that allows automatic reaction monitoring and optimization is discussed.