Mammalian oocyte development: checkpoints for competence
Mammalian oocyte development: checkpoints for competence
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DOI：
10.1071/rd09216
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发表时间：
2010-01-01
影响因子：
1.9
通讯作者：
Fair, Trudee
中科院分区：
文献类型：
--
作者：
Fair, Trudee
在女性的一生中，卵巢环境发生了生化变化。这些变化是由许多内源性和外源性因素引起的，包括畜牧业实践，生产需求和疾病，并可能对卵巢卵母细胞质量和随后的胚胎发育产生深远的影响。尽管有许多研究，但关于卵泡卵母细胞发育的时间或时期对损伤特别敏感还没有达成共识。在这里，发生在卵母细胞和卵泡生长过程中的关键分子和形态学事件进行审查，特别侧重于确定卵母细胞发育的关键检查点。次级卵泡阶段似乎是卵泡卵母细胞发育中的关键阶段，因为主要事件如卵母细胞转录组的激活、透明质酸的隔离、颗粒细胞和卵母细胞之间的双向通信的建立以及皮质颗粒合成发生在该发育期间。几个月后，围排卵期也以发生关键事件为特征，包括mRNA转录物的适当降解或多聚腺苷酸化，减数分裂的恢复，纺锤体形成，染色体排列和分离，因此也应该被视为卵母细胞发育的潜在检查点。
During the lifespan of the female, biochemical changes occur in the ovarian environment. These changes are brought about by numerous endogenous and exogenous factors, including husbandry practices, production demands and disease, and can have a profound effect on ovarian oocyte quality and subsequent embryo development. Despite many investigations, there is no consensus regarding the time or period of follicular oocyte development that is particularly sensitive to insult. Here, the key molecular and morphological events that occur during oocyte and follicle growth are reviewed, with a specific focus on identifying critical checkpoints in oocyte development. The secondary follicle stage appears to be a key phase in follicular oocyte development because major events such as activation of the oocyte transcriptome, sequestration of the zona pellucida, establishment of bidirectional communication between the granulosa cells and the oocyte and cortical granule synthesis occur during this period of development. Several months later, the periovulatory period is also characterised by the occurrence of critical events, including appropriate degradation or polyadenylation of mRNA transcripts, resumption of meiosis, spindle formation, chromosome alignment and segregation, and so should also be considered as a potential checkpoint of oocyte development.