Xylitol candies in caries prevention: results of a field study in Estonian children
Xylitol candies in caries prevention: results of a field study in Estonian children
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DOI：
10.1034/j.1600-0528.2000.280308.x
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发表时间：
2000-06-01
影响因子：
2.3
通讯作者：
Gutmann, K
中科院分区：
文献类型：
--
作者：
Alanen, P;Isokangas, P;Gutmann, K
所有现场研究均明确报告了与使用含木糖醇的口香糖相关的龋齿发生率显著降低。迄今为止，除了口香糖之外，还没有其他木糖醇产品进行过田间试验。1994年在爱沙尼亚开始了一项为期5年的随访研究，其中包括2年或3年的木糖醇消费期，在基线检查时对12所学校的740名10岁儿童进行了调查。在这项研究中，根据基线龋齿经验组成了3个群组，每个群组包括3-5所学校。这些产品在上学期间每天在老师的监督下使用3次，但在周末或S月暑假期间不使用。木糖醇的每日剂量在所有组中为5g。每年9月，由两名经验丰富的临床医生对这些儿童进行检查。根据WHO标准记录龋齿。3年后，与相应的对照组相比，所有木糖醇组均显示出非常显著的龋齿发生率降低35%-60%。木糖醇组中糖果之间、糖果和口香糖之间以及2年和3年使用者之间的差异是非系统性的，表明各组之间没有趋势。结果表明，不仅木糖醇口香糖，而且木糖醇糖果是有效的防龋，和以学校为基础的交付系统似乎提供了一个实用的方法来分配和控制使用的木糖醇产品。
All field studies have unequivocally reported significant reductions in dental caries occurrence associated with the use of chewing gum containing xylitol. No other xylitol products besides chewing gum have so far been tested in field trials. A 5-year follow-up study with 2- or 3-year xylitol consumption periods began in Estonia in 1994 with 740 10-year-old children in 12 schools at baseline examinations. For the study, 3 clusters each including 3-5 schools were formed on the basis of baseline caries experience. The products were used under the supervision of the teachers 3 times per day during school days but not during weekends or during the S-month summer holiday. The daily dose of xylitol was 5 g in all groups. The children were examined every year in September by two experienced clinicians. Dental caries was recorded according to WHO criteria. After 3 years, all xylitol groups showed a highly significant 35%-60% reduction in caries incident, compared with the corresponding control groups. The differences between candies, between candies and chewing gum, and between 2- and 3-year users in the xylitol groups were non-systematic, indicating no trends between the groups. The results suggest that not only xylitol chewing gum but also xylitol candies are effective in caries prevention, and that a school-based delivery system seems to offer a practical way to distribute and control the use of the xylitol products.