Estimating African American admixture proportions by use of population-specific alleles
Estimating African American admixture proportions by use of population-specific alleles
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DOI：
10.1086/302148
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发表时间：
1998-12-01
影响因子：
9.8
通讯作者：
Shriver, MD
中科院分区：
文献类型：
--
作者：
Parra, EJ;Marcini, A;Shriver, MD
我们使用9个常染色体DNA标记分析了欧洲对美国（伊利诺伊州梅伍德、底特律、纽约、费城、匹兹堡、巴尔的摩、南卡罗来纳州查尔斯顿、新奥尔良和休斯顿）和牙买加10个非洲裔人群的遗传贡献。这些标记要么是群体特异性的，要么在亲本群体之间显示出约45%的频率差异，因此对混合具有特别的信息。欧洲遗传祖先的范围从6.8%（牙买加）到22.5%（新奥尔良）。这些标记的独特效用反映在与这些混合物估计相关的低方差上（SEM为1.3%-2.7%）。我们还根据信息丰富的mtDNA（单倍群H和L）和Y Alu多态性标记估计了欧洲男性和女性对非裔美国人的贡献。结果表明，来自欧洲的基因流存在性别偏见，男性的贡献远远大于女性的贡献。mtDNA单倍群分析显示，没有证据表明母亲美洲印第安人对这10个种群中的任何一个都有重大贡献。我们检测到两个标记（FY-null和AT3）之间存在显著的非随机关联，这很可能是由于在两个亲本群体的杂交中产生的混合连锁不平衡。这种关联的强度以及FY和AT3之间巨大的遗传距离强调了受仰慕群体作为绘制亲本群体中不同流行性状的有用资源的重要性。
We analyzed the European genetic contribution to 10 populations of African descent in the United States (Maywood, Illinois; Detroit; New York; Philadelphia; Pittsburgh; Baltimore; Charleston, South Carolina; New Orleans; and Houston) and in Jamaica, using nine autosomal DNA markers. These markers either are population-specific or show frequency differences >45 % between the parental populations and are thus especially informative for admixture. European genetic ancestry ranged from 6.8% (Jamaica) to 22.5% (New Orleans). The unique utility of these markers is reflected in the low variance associated with these admixture estimates (SEM 1.3%-2.7%). We also estimated the male and female European contribution to African Americans, on the basis of informative mtDNA (haplogroups H and L) and Y Alu polymorphic markers. Results indicate a sex-biased gene flow from Europeans, the male contribution being substantially greater than the female contribution. mtDNA haplogroups analysis shows no evidence of a significant maternal Amerindian contribution to any of the 10 populations. We detected significant nonrandom association between two markers located 22 cM apart (FY-null and AT3), most likely due to admixture linkage disequilibrium created in the interbreeding off the two parental populations. The strength of this association and the substantial genetic distance between FY and AT3 emphasize the importance of admired populations as a useful resource for mapping traits with different prevalence in two parental populations.