Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases.
Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases.
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脂基纳米载体作为眼内疾病局部给药系统。
DOI：
10.3390/pharmaceutics13050678
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发表时间：
2021-05-09
期刊：
影响因子：
5.4
通讯作者：
Santos A
中科院分区：
文献类型：
--
作者：
Navarro-Partida J;Castro-Castaneda CR;Santa Cruz-Pavlovich FJ;Aceves-Franco LA;Guy TO;Santos A
由于复杂的解剖和生理障碍选择性地限制药物进入眼内，有效地将药物输送到眼内组织仍然是一个巨大的挑战。为了克服这些挑战，目前使用频繁的局部应用和定期玻璃体内注射来达到所需的眼内药物浓度。然而，重复安装或反复注射可能会导致几种副作用。基于纳米颗粒的药物输送领域的最新进展表明，局部眼科纳米疗法在治疗眼内疾病方面取得了良好的结果。研究表明，纳米载体可以提高蛋白质、多肽和遗传物质等多种疗法的眼内半衰期和生物利用度。在当今可用的纳米粒子阵列中，基于脂质的纳米系统在局部制剂中显示出更高的效率和可行性，使其成为临床前和临床实践中持续和深入研究的重要目标。在这篇综述中，我们将介绍基于脂类的纳米载体在眼内给药外用制剂中的应用前景。
Effective drug delivery to intraocular tissues remains a great challenge due to complex anatomical and physiological barriers that selectively limit the entry of drugs into the eye. To overcome these challenges, frequent topical application and regular intravitreal injections are currently used to achieve the desired drug concentrations into the eye. However, the repetitive installation or recurrent injections may result in several side effects. Recent advancements in the field of nanoparticle-based drug delivery have demonstrated promising results for topical ophthalmic nanotherapies in the treatment of intraocular diseases. Studies have revealed that nanocarriers enhance the intraocular half-life and bioavailability of several therapies including proteins, peptides and genetic material. Amongst the array of nanoparticles available nowadays, lipid-based nanosystems have shown an increased efficiency and feasibility in topical formulations, making them an important target for constant and thorough research in both preclinical and clinical practice. In this review, we will cover the promising lipid-based nanocarriers used in topical ophthalmic formulations for intraocular drug delivery.