The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens
The Dominant white mutation in the PMEL17 gene does not cause visual impairment in chickens
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DOI：
10.1111/j.1463-5224.2009.00714.x
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发表时间：
2009-09-01
影响因子：
1.6
通讯作者：
Jensen, Per
中科院分区：
文献类型：
--
作者：
Karlsson, Anna-Carin;Kerje, Susanne;Jensen, Per
目的探讨显性白色突变是否影响鸡的视觉能力并导致眼部异常。对显性白色突变纯合子和野生型等位基因进行了视觉对比行为试验，并进行了组织学和眼科检查。结果在视觉对比行为试验中，显性白色突变和野生型等位基因纯合的雏鸡在视觉对比行为试验中没有差异，在眼科检查中也没有发现异常结构。结论PMEL17基因的显性白色突变对鸡的视觉能力和眼结构无明显影响。
ObjectiveTo examine whether the Dominant white mutation (causing a hypopigmented phenotype in chicken) affects the visual ability and gives rise to ocular abnormalities in chickens (Gallus gallus).ProcedureChickens homozygous for either the Dominant white mutation or the wild-type alleles were tested in a visual contrast behavioral test and subjected to histological and ophthalmologic examination.ResultsThere were no differences between the genotypes in the visual contrast behavioral test, and there were no abnormal structures among the Dominant white chickens in the ophthalmic examination. The histological sections from the Dominant white chickens did not differ from the wild-type chicken in structure, photoreceptor density, or RPE pigmentation.ConclusionsThe results indicate that the Dominant white mutation in PMEL17 does not seem to affect the visual ability or eye structures in chickens.