Do aggressive and non-aggressive antisocial behaviors in adolescents result from the same genetic and environmental effects?
Do aggressive and non-aggressive antisocial behaviors in adolescents result from the same genetic and environmental effects?
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DOI：
10.1002/ajmg.b.30045
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发表时间：
2004-08-15
影响因子：
2.8
通讯作者：
McGuffin, P
中科院分区：
文献类型：
--
作者：
Button, TMM;Scourfield, J;McGuffin, P
青少年的反社会行为（ASB）大致可以分为两种形式：攻击性和非攻击性。两者都是可遗传的，并且已经表明侵略性ASB更易遗传。基因在多大程度上促成了两者之间的相关性尚不清楚。应用结构方程模型对258对11-18岁的双胞胎样本进行研究，以估计每种形式的ASB的遗传力，并估计表型相关性在多大程度上是共享基因和环境因素的结果。非共享的环境和遗传因素影响了这两种形式的ASB。攻击性ASB的遗传度在女孩中显著高于男孩，但非攻击性ASB的遗传度在女孩中不显著。结合两种性别，一个模型，其中的遗传效应对侵略性和非侵略性ASB是相同的，可以被拒绝。我们的研究结果表明，部分遗传重叠与特定的遗传效应的方差侵略性ASB和更强的遗传效应，在女性比男性的侵略。(C)2004 Wiley-Liss，Inc.
Antisocial behavior (ASB) in adolescents can broadly be separated into two forms; aggressive and non-aggressive. Both are heritable and it has been suggested that aggressive ASB is more heritable. The extent to which genes contribute to the correlation between the two is unknown. Structural equation modeling was applied to a population-based twin sample of 258 twins pairs aged 11-18 to estimate the heritability of each form of ASB and to estimate the extent to which the phenotypic correlation was the consequence of shared genes and environmental factors. Nonshared environment and genetic factors substantially influenced both forms of ASB. The heritability of aggressive (but not non-aggressive) ASB was significantly higher in girls than in boys. Combining both sexes, a model in which the genetic effects on aggressive and non-aggressive ASB were identical could be rejected. Our results suggest a partial genetic overlap with a specific genetic effect contributing to the variance of aggressive ASB and a stronger genetic effect on aggression in females than in males. (C) 2004 Wiley-Liss, Inc.