A developmental timing microRNA and its target regulate life span in C. elegans
A developmental timing microRNA and its target regulate life span in C. elegans
复制标题
DOI：
10.1126/science.1115596
复制
发表时间：
2005-12-23
期刊：
影响因子：
56.9
通讯作者：
Slack, F
中科院分区：
文献类型：
--
作者：
Boehm, M;Slack, F
微小RNA（microRNA）lin - 4及其靶标，即假定的转录因子lin - 14，控制着秀丽隐杆线虫幼虫发育的时间。在此，我们报道lin - 4和lin - 14也调节成虫的寿命。降低lin - 4的活性会缩短寿命并加速组织衰老，而过量表达lin - 4或降低lin - 14的活性则会延长寿命。由lin - 14活性降低所带来的寿命延长依赖于DAF - 16和HSF - 1转录因子，这表明lin - 4 - lin - 14这一对因子通过胰岛素/胰岛素样生长因子 - 1途径影响寿命。这项工作揭示了微小RNA和发育时序基因在寿命调控中的作用。
The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Life-span extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4-lin-14 pair affects life span through the insulin/insulin-like growth factor-1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.