OXYGEN-TOXICITY IN NEONATAL AND ADULT ANIMALS OF VARIOUS SPECIES
OXYGEN-TOXICITY IN NEONATAL AND ADULT ANIMALS OF VARIOUS SPECIES
复制标题
DOI：
10.1152/jappl.1978.45.5.699
复制
发表时间：
1978-01-01
影响因子：
3.3
通讯作者：
ROBERTS, RJ
中科院分区：
文献类型：
--
作者：
FRANK, L;BUCHER, JR;ROBERTS, RJ
新生和成年动物5只。暴露在>；95%O2中。测定小鼠存活时间和肺组织抗氧化酶[超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GP)]活性在高氧条件下的变化。成年动物，在3-5天内死于氧气肺中毒。新生大鼠、小鼠和兔在高氧暴露7天后，肺组织出现轻微的变化，这些新生动物的肺抗氧化酶活性迅速而显著地增加。新生的豚鼠和仓鼠没有肺抗氧化酶对高氧的反应，这些新生的动物和它们各自的亲代动物一样容易在95%的氧气中死亡。体外高氧暴露系统的结果表明，豚鼠(和仓鼠)新生儿对O2挑战缺乏酶反应是由于固有的肺生化无反应，而不是由于缺乏必要的血清因子。支持肺抗氧化酶防御系统在保护肺免受O2损伤中的重要作用。
Neonatal and adult animals of 5 spp. were exposed to > 95% O2. Survival time and changes in lung antioxidant enzyme activity [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GP)] in response to hyperoxia were determined. Adult animals, succumbed to O2 lung toxicity in 3-5 days. Neonatal rats, mice and rabbits showed minimal lung changes after 7 days of hyperoxic exposure and these same neonatal animals showed rapid and significant increases in lung antioxidant enzyme activities. Neonatal guinea pigs and hamsters had no lung antioxidant enzyme response to hyperoxia and these neonates died in > 95% O2 as readily as their respective parent animals. Results from an in vitro hyperoxic exposure system suggest that the lack of enzymic response of the guinea pig (and hamster) neonates to O2 challenge is due to an inherent pulmonary biochemical unresponsiveness rather than to a deficiency of a necessary serum factor. The important role of the lung antioxidant enzyme defense system in protection of the lung from O2-induced injury is supported.