Possible effects of endocrine disruptors on male reproductive function.
Possible effects of endocrine disruptors on male reproductive function.
复制标题
内分泌干扰物对男性生殖功能的可能影响。
DOI：
--
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
C. Mori
中科院分区：
文献类型：
--
作者：
C. Mori
内分泌干扰物的作用是改变血液激素水平或激素的后续作用，包括对激素的产生、释放、运输、代谢和/或消除的影响，以及对同源受体结合和/或随后的细胞内受体作用的影响。野生物种生殖发育的已证实的改变，加上世界某些地区人类男性生殖道异常发生率增加和成年精子数量减少的报告，增加了公众对内分泌干扰物的关注。一种生物学上似是而非的假设表明，人造化学物质作为内分泌干扰物，导致生殖道发育发生改变，从而产生了所观察到的影响。根据目前的知识，内分泌干扰物对男性生殖功能的影响仍有待观察。人类流行病学研究对于填补我们的知识空白是必要的。人类在胎儿或出生后发育过程中激素调节的紊乱可能对男性生殖系统产生不利影响，但这些内分泌干扰物对人类的不利影响是微妙的，难以研究和检测。我们通过分析脐带来研究日本胎儿对内分泌干扰物的暴露，并通过尸检分析数据来研究日本男性睾丸重量的变化。本文就内分泌干扰物对男性生殖功能可能产生的影响及近期研究成果进行综述。
Endocrine disruptors act to alter blood hormone levels or the subsequent action of hormones, including effects on hormone production, release, transport, metabolism and/or elimination together with effects on cognate receptor binding and/or subsequent intracellular receptor actions. Confirmed alterations in reproductive development in wildlife species together with reports touting an increase in the incidence of human male reproductive tract abnormalities and decreased adult sperm counts in some parts of the world have increased public concern with endocrine disruptors. A biological plausible hypothesis has suggested that man-made chemicals act as endocrine disruptors resulting in altered development of the reproductive tract causing the observed effects. Based on current knowledge, the impact of endocrine disruptors on the male reproductive function remains to be appreciated. Epidemiological human studies are necessary to fill in the gap in our knowledge. Disturbances of hormonal regulation during fetal or postnatal development in humans may induce adverse effects on the male reproductive system, but these adverse effects of endocrine disruptors on humans are subtle, and difficult to research and detect. We have investigated fetal exposure to endocrine disruptors in Japan by analyzing umbilical cords, and changes of testis-weight in Japanese men by using analytical data of necropsy. This mini-review summarizes current endocrine disruptor issues on possible effects of endocrine disruptors on male reproductive function and the results of our recent research.