Brain white matter expansion in human obesity and the recovering effect of dieting
Brain white matter expansion in human obesity and the recovering effect of dieting
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DOI：
10.1210/jc.2006-2495
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发表时间：
2007-08-01
影响因子：
5.8
通讯作者：
Kaasinen, Valtteri
中科院分区：
文献类型：
--
作者：
Haltia, Lauri T.;Viljanen, Antti;Kaasinen, Valtteri
背景和目的：肥胖与多种代谢异常有关。最近的研究表明，肥胖也会影响大脑功能，是一些退行性脑部疾病的危险因素。本研究的目的是检查体重增加和体重减轻对脑灰质和白色物质结构的影响。我们假设肥胖者大脑中可能存在的差异在强化节食后会消失或减少。方法：在研究的第一部分，我们用磁共振成像扫描了16名瘦（平均体重指数，22 kg/m2）和30名肥胖（平均体重指数，33 kg/m2）的健康受试者。在第二部分中，16名肥胖受试者继续与一个非常低热量的饮食6周，之后，他们再次扫描。区域脑白色和灰质体积计算使用基于体素的morphometry.Results：白色物质的体积在肥胖的受试者更大，与瘦的受试者在几个基底脑区域，和肥胖个体表现出正相关性白色物质体积在基底脑结构和腰臀比。检测到的白色物质扩张部分逆转节食。区域灰质体积没有显着差异，肥胖和瘦的科目，节食并没有影响graymatter.Conclusions：发现白色物质变化的确切机制仍不清楚，但本研究表明，肥胖和节食与大脑结构的相反变化。不排除肥胖时的白色物质扩张在退行性脑疾病的神经发病机制中具有作用。
Context and Objective: Obesity is associated with several metabolic abnormalities. Recent studies suggest that obesity also affects brain function and is a risk factor for some degenerative brain diseases. The objective of this study was to examine the effects of weight gain and weight loss on brain gray and white matter structure. We hypothesized that possible differences seen in the brains of obese subjects would disappear or diminish after an intensive dieting period.Methods: In part I of the study, we scanned with magnetic resonance imaging 16 lean (mean body mass index, 22 kg/m(2)) and 30 obese (mean body mass index, 33 kg/m2) healthy subjects. In part II, 16 obese subjects continued with a very low-calorie diet for 6 wk, after which they were scanned again. Regional brain white and gray matter volumes were calculated using voxel-based morphometry.Results: White matter volumes were greater in obese subjects, compared with lean subjects in several basal brain regions, and obese individuals showed a positive correlation between white matter volume in basal brain structures and waist to hip ratio. The detected white matter expansion was partially reversed by dieting. Regional gray matter volumes did not differ significantly in obese and lean subjects, and dieting did not affect gray matter.Conclusions: The precise mechanism for the discovered white matter changes remains unclear, but the present study demonstrates that obesity and dieting are associated with opposite changes in brain structure. It is not excluded that white matter expansion in obesity has a role in the neuropathogenesis of degenerative brain diseases.