Thermodynamic implications of high Q 10 of thermo-TRP channels in living cells.
Thermodynamic implications of high Q 10 of thermo-TRP channels in living cells.
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DOI：
10.2142/biophysics.11.33
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yoshioka T
中科院分区：
文献类型：
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作者：
Ito E;Ikemoto Y;Yoshioka T
热瞬态受体电位通道的活性高度依赖于温度，因此热-TRP反应具有较高的温度系数Q10。在热力学中，高的Q10值表明在通道的闭合和打开状态之间的过渡过程中，在短时间内存在大的活化能（即大的焓）。吉布斯自由能方程表明，需要一个大的熵来补偿这个大的焓，并允许通道的激活，这表明通道的构象发生了很大的变化。这些大的焓值和熵值似乎与球形蛋白质展开过程的值相匹配。我们概述了热trps中的这些热力学问题。
The activity of thermo-transient receptor potential (TRP) channels is highly dependent on temperature, and thus thermo-TRP reactions have a high temperature coefficient Q10. In thermodynamics, a high value of Q10 indicates the existence of a large activation energy (i.e., a large enthalpy) over a short period during the transition process between the closed and open states of the channels. The Gibbs free energy equation shows that a large entropy is required to compensate for this large enthalpy and permit activation of the channels, suggesting a large conformational change of the channels. These large values of enthalpy and entropy seem to be a match for the values of the unfolding process of globular proteins. We outline these thermodynamic issues in thermo-TRPs.