The RING finger domain: A recent example of a sequence-structure family
The RING finger domain: A recent example of a sequence-structure family
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DOI：
10.1016/s0959-440x(96)80060-1
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发表时间：
1996-06-01
影响因子：
6.8
通讯作者：
Freemont, PS
中科院分区：
文献类型：
--
作者：
Borden, KLB;Freemont, PS
在过去的18个月中，已经解决了两个RING手指结构。它们代表了这种新的锌结合序列基序的首次报道的结构。这两种结构在它们的锌连接方案和它们的三维结构方面与其他锌结合结构域显著不同。RING指结构域似乎是一个方便的支架，可以改变它以在含有该基序的蛋白质中提供功能特异性。
In the past 18 months, two RING finger structures have been solved. They represent the first reported structures for this novel zinc-binding sequence motif. Both structures are significantly different from other zinc-binding domains, in terms of both their zinc-ligation scheme and their three-dimensional structures. The RING finger domain appears to be a convenient scaffold which can be altered to provide functional specificity in those proteins that contain the motif.