Depression and emotional stress is highly prevalent among women with recurrent pregnancy loss
Depression and emotional stress is highly prevalent among women with recurrent pregnancy loss
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DOI：
10.1093/humrep/dev014
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发表时间：
2015-04-01
影响因子：
6.1
通讯作者：
Nielsen, H. S.
中科院分区：
文献类型：
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作者：
Kolte, A. M.;Olsen, L. R.;Nielsen, H. S.
研究问题：复发性流产（RPL）女性的心理压力和中度/重度抑郁症的患病率是否高于自然怀孕计划者？回答：心理压力和重度抑郁症在RPL女性中明显比那些试图自然受孕的女性更常见。已知事实：RPL对夫妻尤其是女方的情感有重大影响。先前的研究显示出不确定的结果。研究设计、规模、持续时间：在这项横断面研究中，我们比较了301名RPL妇女和1813名试图自然怀孕的妇女的压力和抑郁的患病率。我们将RPL定义为妊娠12周前三次或以上的流产。RPL患者于2010 - 2013年入组，对照组于2011 - 2014年入组。参与者/材料、环境、方法：RPL患者在丹麦RPL单位首次会诊前完成一份在线问卷。此外，我们还纳入了1813名女性的比较组数据，这些女性参加了Soon Parents研究（www.SnartForldre.dk）。重度抑郁指数（MDI）用于评估抑郁症状，科恩感知压力量表（PSS）用于测量压力。还检索了相关的人口统计数据。主要结果和机会的作用：在RPL患者中，26例（8.6%）的MDI得分对应于中度/重度抑郁症，在Soon Parents研究中，40例（2.2%）的女性也有相应的MDI得分(调整优势比（OR） 5.53(95%可信区间（CI）： 2.09；14.61))。124例（41.2%）患者报告高应激水平，对照组420例（23.2%）患者报告高应激水平（95% CI 1.03; 2.44）。局限性和谨慎的原因：我们使用在线问卷，没有访谈数据。我们不知道对照组中是否有女性患有RPL。研究结果的更广泛意义：这项研究应该引起对RPL妇女的护理人员对精神痛苦的高度认识。
STUDY QUESTION: Is the prevalence of psychological stress and moderate/severe depression higher for women with recurrent pregnancy loss (RPL) than pregnancy planners trying to conceive naturally?SUMMARY ANSWER: Both psychological stress and major depression are significantly more common among women with RPL than in those trying to conceive naturally.WHAT IS KNOWN ALREADY: RPL has a significant emotional impact on couples, especially the woman. Previous studies have shown inconclusive results.STUDY DESIGN, SIZE, DURATION: In this cross-sectional study, we compared the prevalence of stress and depression among 301 women with RPL and 1813 women attempting to conceive naturally. We defined RPL as three or more pregnancy losses before 12 weeks' gestation. RPL patients were enrolled from 2010 to 2013 and the comparison group from 2011 to 2014.PARTICIPANTS/MATERIALS, SETTING, METHODS: RPL patients completed an online questionnaire before their first consultation at the Danish RPL Unit. In addition, we included data from a comparison group of 1813 women who participated in the Soon Parents Study (www.SnartForldre.dk). The Major Depression Index (MDI) was used to assess symptoms of depression, and Cohen's Perceived Stress Scale (PSS) was used to measure stress. Relevant demographic data were also retrieved.MAIN RESULTS AND THE ROLE OF CHANCE: Of the RPL patients, 26 (8.6%) had a score on the MDI corresponding to moderate/severe depression, as did 40 (2.2%) of the women in Soon Parents Study (adjusted odds ratio (OR) 5.53 (95% confidence interval (CI): 2.09; 14.61)). A high stress level, defined as >= 19 on the PSS scale, was reported by 124 (41.2%) of the patients and 420 (23.2%) in the comparison group (adjusted OR 1.59 (95% CI 1.03; 2.44)).LIMITATIONS, REASONS FOR CAUTION: We used online questionnaires, and have no interview data. We were unaware if any of the women in the comparison group suffer from RPL.WIDER IMPLICATIONS OF THE FINDINGS: This study should entail a heightened awareness of mental distress among care providers for women with RPL.