Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer
Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer
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DOI：
10.1016/j.jtho.2020.02.010
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发表时间：
2020-05-01
影响因子：
20.4
通讯作者：
Xiao, Shu-Yuan
中科院分区：
文献类型：
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作者：
Tian, Sufang;Hu, Weidong;Xiao, Shu-Yuan
目前，来自尸检或活检的关于新型冠状病毒（严重急性呼吸综合征冠状病毒2）肺炎，即2019冠状病毒病（COVID - 19）的病理数据缺乏。最近有两名因腺癌接受肺叶切除术的患者，经回顾性研究发现手术时患有COVID - 19。因此，这两个病例为研究COVID - 19的病理学提供了重要的首次机会。病理检查显示，除肿瘤外，两名患者的肺部均表现出水肿、蛋白性渗出物、肺细胞局灶性反应性增生伴片状炎症细胞浸润以及多核巨细胞。透明膜不显著。由于两名患者在手术时均未表现出肺炎症状，这些变化可能代表了COVID - 19肺炎肺部病理的早期阶段。（C）2020国际肺癌研究协会。由爱思唯尔公司出版。保留所有权利。
There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) pneumonia, or coronavirus disease 2019 (COVID-19), from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of the operation. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia. (C) 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.