Hsp90 at the crossroads of genetics and epigenetics
Hsp90 at the crossroads of genetics and epigenetics
复制标题
Hsp90 处于遗传学和表观遗传学的十字路口
作者：
Keith S. Wong;W. Houry
Hsp90是一种特殊的分子伴侣，能够缓冲异常表型的表达。抑制Hsp90活性会导致这些表型的表达，否则这些表型是被掩盖的。从受影响的后代杂交中选择后代导致这些表型的遗传和丰富，这些表型可以独立于它们的原始刺激。目前的综合证据支持一种涉及遗传学和表观遗传学相互作用的模型。最近对Hsp90相互作用网络的蛋白质组学研究为这一复杂现象背后的分子机制提供了进一步的线索。本文综述了最近的实验观察结果，并简要讨论了用于解释不同观察结果的遗传学和表观遗传学观点。
Hsp90 is a specialized molecular chaperone that is capable of buffering the expression of abnormal phenotypes. Inhibition of Hsp90 activity results in the expression of these phenotypes that are otherwise masked. Selection of offspring from the crossing of affected progenies results in inheritance and enrichment of these phenotypes, which can become independent of their original stimuli. The current combined evidence favours a model involving the interplay between genetics and epigenetics. The recent proteomics efforts to characterize the Hsp90 interaction networks provide further clues into the molecular mechanisms behind this complex phenomenon. This review summarizes the most recent experimental observations and briefly discusses the genetic and epigenetic views used in explaining the different observations.