Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice
Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice
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DOI：
10.1128/iai.73.3.1847-1851.2005
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发表时间：
2005-03-01
影响因子：
3.1
通讯作者：
Grillot-Courvalin, C
中科院分区：
文献类型：
--
作者：
González-Zorn, B;Senna, JPM;Grillot-Courvalin, C
鼻腔携带是金黄色葡萄球菌感染的主要危险因素，尤其是耐甲氧西林菌株（MRSA）。利用小鼠鼻腔运输模型，我们比较了几种金黄色葡萄球菌菌株，并证明MRSA在囊性纤维化跨膜电导调节因子缺陷小鼠和toll样受体2 （TLR2）缺陷小鼠中的定植水平增加，而tlr4缺陷小鼠则没有。
Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2) -deficient mice but not TLR4-deficient mice.