Enzyme-responsive polymer hydrogel particles for controlled release
Enzyme-responsive polymer hydrogel particles for controlled release
复制标题
DOI：
10.1002/adma.200601784
复制
发表时间：
2007-05-07
影响因子：
29.4
通讯作者：
Ulijn, Rein V.
中科院分区：
文献类型：
--
作者：
Thornton, Paul D.;Mart, Robert J.;Ulijn, Rein V.
本文描述了一种基于聚合物的酶触发释放的新概念方法，即（疾病特异性）酶的选择性催化作用在化学交联的水凝胶颗粒中触发电荷诱导的膨胀反应，导致物理捕获的大分子释放（见图）。
A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).