Relationship between cancer cell proliferation and thallium-201 uptake in lung cancer
Relationship between cancer cell proliferation and thallium-201 uptake in lung cancer
复制标题
肺癌癌细胞增殖与铊201摄取的关系
DOI：
10.1007/bf02988207
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发表时间：
2000
影响因子：
2.6
通讯作者：
N. Hayabuchi
中科院分区：
文献类型：
--
作者：
M. Ishibashi;T. Fujii;H. Yamana;K. Fujimoto;T. Rikimaru;A. Hayashi;Seiji Kurata;N. Hayabuchi
尽管铊-201 (201Tl) 摄取与许多正常组织中的灌注有关，但肿瘤中 201Tl 摄取的生物学原理尚不确定。为了确定肿瘤摄取是否与细胞增殖相关，我们将肺肿瘤中 201Tl 的相对保留与细胞增殖指标 Ki-67 的表达相关联。 方法：60 名肺肿瘤患者，包括小细胞癌 (n=8) 和非小细胞癌 (n=52)，接受了 201Tl 单光子发射计算机断层扫描 (SPECT) 成像。在早期和延迟图像上测定201T1病变摄取并计算放射性示踪剂保留指数(RI)。肿瘤标本通过手术或支气管镜检查获得。用识别核抗原Ki-67的单克隆抗体MIB-1估计细胞增殖率。结果：平均201T1指数为2.13±0.61（早期）和2.46±0.83（延迟）。平均RI为17.44±35.01。总体而言，201T1指数（延迟）与癌细胞增殖相关（r=0.70，p<0.0001）。有趣的是，延迟图像上的201T1指数与小细胞肺癌而非非小细胞肺癌患者的细胞增殖率之间存在显着相关性（r=0.872，p<0.0005）。小细胞肺癌患者的201Tl指数（延迟）显着高于非小细胞肺癌患者（p<0.0001）。结论：201Tl成像似乎可用于评估小细胞肺癌患者，但不适用于非小细胞肺癌患者，并且与细胞增殖标志物单克隆抗体MIB-1相关。
Although thallium-201 (201Tl) uptake is related to perfusion in many normal tissues, the biologic rationale for201Tl uptake in tumors is uncertain. To determine if tumor uptake is related to cell proliferation, we correlated the relative retention of201Tl in lung tumors with expression of Ki-67, an indicator of cell proliferation.Methods: Sixty patients with lung tumors, included small cell carcinoma (n=8) and non-small cell carcinoma (n=52), underwent201Tl single photon emission computed tomography (SPECT) imaging. The201Tl lesion uptake was determined on early and delayed images and the radiotracer retention index (RI) was calculated. Tumor specimens were obtained at surgery or bronchoscopy. The cell proliferation ratio was estimated with MIB-1, a monoclonal antibody that recognized the nuclear antigen Ki-67.Results: The average201Tl index was 2.13±0.61 (early) and 2.46±0.83 (delayed). The average RI was 17.44±35.01. Overall, the201Tl index (delayed) and the cancer cell proliferation were correlated (r=0.70, p<0.0001). Of interest, there was a significant correlation (r=0.872, p<0.0005) between the201Tl index on delayed images and the cell proliferation ratio in patients with small cell but not non-small cell lung carcinoma. The201Tl index (delayed) was significantly higher (p<0.0001) in patients with small cell lung carcinoma than in patients with non-small cell lung carcinoma.Conclusion:201Tl imaging appears to be useful for evaluating patients with small cell lung carcinoma but not non-small lung carcinoma, and is correlated with the monoclonal antibody MIB-1, a marker of cell proliferation.
人体肿瘤异种移植物中的体内溴脱氧尿苷标记。
影响因子：
2.6
作者：
Parkins,CS;Begg,AC;Bush,C;Price,P;Imrie,PR;Ormerod,MG;Steel,GG
通讯作者：
Steel,GG
肿瘤细胞中 99mTc-MIBI 和 201Tl-氯化亚铊积累的差异：P-糖蛋白的作用。
DOI：
--
发表时间：
1995
期刊：
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)
影响因子：
--
作者：
Ballinger,JR;Sheldon,KM;Boxen,I;Erlichman,C;Ling,V
通讯作者：
Ling,V