Raised serum APRIL levels in patients with systemic lupus erythematosus
Raised serum APRIL levels in patients with systemic lupus erythematosus
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DOI：
10.1136/ard.2004.022491
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发表时间：
2005-07-01
影响因子：
27.4
通讯作者：
Horiuchi, T
中科院分区：
文献类型：
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作者：
Koyama, T;Tsukamoto, H;Horiuchi, T
目的：目的：探讨系统性红斑狼疮（SLE）患者血清中增殖诱导配体（APRIL）水平是否升高，并与自身抗体滴度或疾病活动性相关。方法：采用酶联免疫吸附试验（ELISA）检测48例SLE患者、41例正常人和21例类风湿关节炎（RA）患者血清中APRIL水平。回顾性分析病历中的自身抗体滴度和免疫球蛋白水平。结果：SLE患者血清中APRIL水平显著高于健康对照组和RA患者。血清APRIL水平与血清IgG和IgM水平不相关，但有与抗双链DNA抗体滴度相关的趋势。此外，血清APRIL水平与SLE患者的肌肉骨骼表现显着相关时，BILAG指数评估。结论：APRIL可能是一个重要的因素，在SLE患者的自身抗体滴度升高和肌肉骨骼疾病。血清APRIL水平升高的患者可能是APRIL治疗靶向的理想候选者。
Objective: To determine whether serum levels of a proliferation-inducing ligand ( APRIL) are raised in patients with systemic lupus erythematosus (SLE) and correlate with autoantibody titres or disease activity, or both.Methods: Serum samples from 48 patients with SLE, 41 normal healthy subjects, and 21 patients with rheumatoid arthritis ( RA) were assayed for APRIL by enzyme linked immunosorbent assay. Medical charts were retrospectively reviewed for autoantibody titres and immunoglobulin levels. Disease activity was assessed using the British Isles Lupus Assessment Group (BILAG) index.Results: The APRIL levels in the serum samples from patients with SLE were significantly higher than in those from healthy controls and those from patients with RA. Serum APRIL levels did not correlate with serum IgG and IgM levels, but had a tendency to correlate with anti-double stranded DNA antibody titres. Moreover, serum APRIL levels correlated significantly with musculoskeletal manifestations among patients with SLE when assessed by the BILAG index.Conclusion: APRIL may be an important factor in raised autoantibody titres and musculoskeletal disease in patients with SLE. Patients with raised serum APRIL levels may be ideal candidates for therapeutic targeting of APRIL.