Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract
Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract
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DOI：
10.1093/humupd/6.5.495
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发表时间：
2000-09-01
影响因子：
13.3
通讯作者：
Miell, JP
中科院分区：
文献类型：
--
作者：
Fowler, DJ;Nicolaides, KH;Miell, JP
胰岛素样生长因子-1（IGFBP-1）在人类女性生殖生理学中特别重要，其中它与调节月经周期、青春期、排卵、蜕膜化、植入和胎儿生长的复杂系统中的其它因子有关。这对临床产科和妇科学有意义，其中有证据表明IGPBP-1在先兆子痫、子宫内生长受限、多囊卵巢综合征以及滋养层和子宫内膜肿瘤中的病理生理作用。
Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGPBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.